ID A4AWP7_MARSH Unreviewed; 1081 AA.
AC A4AWP7;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN OrderedLocusNames=FB2170_01836 {ECO:0000313|EMBL:EAQ99661.1};
OS Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Maribacter.
OX NCBI_TaxID=313603 {ECO:0000313|EMBL:EAQ99661.1, ECO:0000313|Proteomes:UP000001602};
RN [1] {ECO:0000313|EMBL:EAQ99661.1, ECO:0000313|Proteomes:UP000001602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX PubMed=21037013; DOI=10.1128/JB.01207-10;
RA Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA Cho J.C.;
RT "Complete genome sequence of strain HTCC2170, a novel member of the genus
RT Maribacter in the family Flavobacteriaceae.";
RL J. Bacteriol. 193:303-304(2011).
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; CP002157; EAQ99661.1; -; Genomic_DNA.
DR RefSeq; WP_013305060.1; NC_014472.1.
DR AlphaFoldDB; A4AWP7; -.
DR STRING; 313603.FB2170_01836; -.
DR KEGG; fbc:FB2170_01836; -.
DR eggNOG; COG0793; Bacteria.
DR eggNOG; COG4946; Bacteria.
DR HOGENOM; CLU_005503_1_0_10; -.
DR OrthoDB; 9815657at2; -.
DR Proteomes; UP000001602; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 3.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Reference proteome {ECO:0000313|Proteomes:UP000001602};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}.
FT DOMAIN 832..1035
FT /note="Tail specific protease"
FT /evidence="ECO:0000259|SMART:SM00245"
FT ACT_SITE 744
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 966
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1024
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT SITE 967
FT /note="Transition state stabilizer; via amide nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-3"
SQ SEQUENCE 1081 AA; 122060 MW; B07364B8E4F935D9 CRC64;
MILKIKIAKL FPLLLTLILL LANTVRSQGF EGYYQYPDVH GNKVVFAAEG DIWTVPLSGG
LAYKLTTHAE EERYPAISPD GKMIAFSASY EGPTEIYSMP IDGGLPIRWT YESDFSRTNG
WTPDGKIVYD TRAFATLPDR QLVTIDIKTK KKVRVPLSQA SEASFDASGN TVFFVRPSDH
GNVTKRYKGG TARQIWKFTN ESTEAIQLTK GYAGESHHPM WFNARVYFIT DRDGIMNIWS
IDENGNDLKQ HTDHTDFDVR YANLHKGNIV YQIGADIWHY NIQNNNKKKI NIKLTSDLDQ
LREKWVENPS KYITSVNPDK KGERIVITAR GRAFVAPVKS GRLVEFTDKK NVRFRDAVFS
SDGKKVYTLS DESGEFEFVS MPSNGVGSHE AITNNGKVLR YAGKPSPDGK WLAYDDLMGN
MFVLNIATGS SKKISTKEEG IYSFSWSPDS KWIAFVQVAD NTMAQIYLYG LSSGASFPIT
TDRANSNYPA WSPDGKFIYF LSDRNFTTLV GSPWGPRQPE PYFDASEKLY HIALQKGTRS
PFRAKDELAP VEKKEDKEDG SNSVAVKVDR DGIQERIEEV PLKPGNYRGL AVTKKAVYLM
SRETGVDAKT HLGVLKIDNE DVKLKTMMED VRSFGLTGDT KQLLVRQKNN FYMVDAGTGK
VSDLADKKID LSGWKFAITP QEDWKQIFRD AWRMERDYFY DKNMHGVNWK AMHDKYYALI
DRITTRNELS DLIGRFVGEL AALHTSVRGG DVRGDSKNIS VADLGARFSR DEANGGFRIE
HIYRADPDYP DEKSPLDDPF LDIRVGDVIT GINGKQALSA VDIGELIRNQ QGKQVRIEIK
RGTVKKNVIV KPIGSTYRLR YRDWEYSRRL AVEKATESKI GYVHLQAMGS SDLNQWYREF
YPVFDRPGLI IDVRHNRGGN IESFILEKLL RKAWMYWKSR SGKPYWNMQY AFRGHIVVLV
NGNTASDGEA FADGFKKLNL GTAIGTRTWG GEIWLSGVNR LSDGGIARAP MMGVYGPDGD
WLIEGHGFEP DIVVDNLPHA TFNGKDAQLD AAIEHLEKLI AKDPRQVPNP PAYPDKSFNN
K
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