ID A4B9D3_9GAMM Unreviewed; 797 AA.
AC A4B9D3;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=MED297_20142 {ECO:0000313|EMBL:EAR11234.1};
OS Reinekea blandensis MED297.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Saccharospirillaceae; Reinekea.
OX NCBI_TaxID=314283 {ECO:0000313|EMBL:EAR11234.1, ECO:0000313|Proteomes:UP000005953};
RN [1] {ECO:0000313|EMBL:EAR11234.1, ECO:0000313|Proteomes:UP000005953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED297 {ECO:0000313|EMBL:EAR11234.1,
RC ECO:0000313|Proteomes:UP000005953};
RA Pinhassi J., Pedros-Alio C., Ferriera S., Johnson J., Kravitz S.,
RA Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R.,
RA Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR11234.1}.
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DR EMBL; AAOE01000001; EAR11234.1; -; Genomic_DNA.
DR RefSeq; WP_008044757.1; NZ_CH724151.1.
DR AlphaFoldDB; A4B9D3; -.
DR STRING; 314283.MED297_20142; -.
DR HOGENOM; CLU_014785_0_1_6; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000005953; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF49; LON PROTEASE HOMOLOG-RELATED; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000005953};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 564..759
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 797 AA; 89507 MW; 0433FC222B57301F CRC64;
MSTLPSPLAA SDLTAQIDLS HLNIESTADL DGVSSFLGQP RAKKSLEFGI AMRGSGYNLY
VMGDSGTGRQ SLVSKYVRGL AESQQAPSEW AYINNFESPR EPSALEVPAG RGDVLKEQIQ
QLVNDLMDTF PSAFENPTYQ RKRTMIDREF NQKYDMAIKL VERFANEKEV AVVADGGSVM
LLPVIDGKAL DDTEFAQLPE QVRSEFQSRI NDIEEYLNEQ VLELPTWRRK SSEKLRQLNL
ETVQQAIRPL IKELEVKNQS QLSILRYIRE VKNHLPQQIV DLFAEESMMD TRTDQDRRAA
LEGWLKPNLM TQHEINDGAP VIYEMLPTYQ NLFGRIEYAT QQGIPITNYQ LIRPGSLLRA
NGGYLILDAE KLLIEPYAWD ALKLALKTKE LKMESPYADA SLMHAVTLSP ESIRLNVKVV
LLGSRDIYYQ LQEWDPEFME LFRVPVDFDS FIPSNRDNID NLILRIKDYG ETKGFKPLTK
AALERLIEYS LREAEHQKRL SAQVAKVFKV FAEADYISRH KEARFIEASH VTEALEAADY
RNSRIADQML QEIEEGTILI DTDGQRVGCV NGLTVMEIGE SCFGSPARIT ATVHVGGKGV
VDIEREVELG QSIHSKGVMI LSGFLGHEFG RQFPLTLSSH IAMEQSYGYI DGDSATVAEY
CSLLSAITQA PVNQHLAITG SMNQLGEVQA IGGVNEKIEG FFKLCQLRGL NGRQGVIIPA
DNQKHLMLHQ SVIDAVEAGQ FHIYSVRHVY QALALLMDRE PGEVSDKGEF PESSLNGQAQ
TALKKLFELY QETEEGE
//
