ID A4C9M6_9GAMM Unreviewed; 394 AA.
AC A4C9M6;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Acetyl-CoA acetyltransferase with thiolase domain {ECO:0000313|EMBL:EAR28084.1};
GN ORFNames=PTD2_19752 {ECO:0000313|EMBL:EAR28084.1};
OS Pseudoalteromonas tunicata D2.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=87626 {ECO:0000313|EMBL:EAR28084.1, ECO:0000313|Proteomes:UP000006201};
RN [1] {ECO:0000313|EMBL:EAR28084.1, ECO:0000313|Proteomes:UP000006201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D2 {ECO:0000313|EMBL:EAR28084.1,
RC ECO:0000313|Proteomes:UP000006201};
RA Moran M.A., Kjelleberg S., Egan S., Saunders N., Thomas T., Ferriera S.,
RA Johnson J., Kravitz S., Halpern A., Remington K., Beeson K., Tran B.,
RA Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR28084.1}.
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DR EMBL; AAOH01000004; EAR28084.1; -; Genomic_DNA.
DR RefSeq; WP_009839916.1; NZ_CH959301.1.
DR AlphaFoldDB; A4C9M6; -.
DR STRING; 87626.PTD2_19752; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_0_1_6; -.
DR OrthoDB; 8951704at2; -.
DR Proteomes; UP000006201; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF144; ACYL-COA THIOLASE-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EAR28084.1}.
FT DOMAIN 7..263
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 271..392
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 350
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 380
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 394 AA; 40372 MW; 363ED66571569912 CRC64;
MSVQDPIVIV AASRTPMGGF MGALSDVHTT DLGATAIAHA VAQSGVSVND IDEVIMGCVL
PAGVGQAPAR QAMLKAQLPL GTGATTINKV CGSGLKAAMF AHDLISAGSI NIAVAGGMEN
MSASPYFLPK ARGGFRMGHG EIKDHMMADG LEDAYDKKAM GCFAQETANE YGITRADMDA
FAINSLQKAQ AAIASGAFIG EVAPVTYATR SGDVVVSIDE QPGNAKVDKI PTLRPAFAKE
GTITAANSSS ISDGAAALVL MKASDAQAKG LTPLCKIVAH ATHSQKPAEF TVAPVGAMNK
VLIKAGWSTE QVDLWEINEA FAMVTMLAIN EMKLDSAKVN VNGGACALGH PIGASGARIL
VTLIHALKNR NLKTGVASLC IGGGEAVAMA IELI
//
