ID   A4EKC3_9RHOB            Unreviewed;       347 AA.
AC   A4EKC3;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=RCCS2_17116 {ECO:0000313|EMBL:EBA11670.1};
OS   Roseobacter sp. CCS2.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseobacter.
OX   NCBI_TaxID=391593 {ECO:0000313|EMBL:EBA11670.1, ECO:0000313|Proteomes:UP000003535};
RN   [1] {ECO:0000313|EMBL:EBA11670.1, ECO:0000313|Proteomes:UP000003535}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS2 {ECO:0000313|EMBL:EBA11670.1,
RC   ECO:0000313|Proteomes:UP000003535};
RA   Mary Ann M.A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EBA11670.1}.
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DR   EMBL; AAYB01000003; EBA11670.1; -; Genomic_DNA.
DR   RefSeq; WP_008234577.1; NZ_AAYB01000003.1.
DR   AlphaFoldDB; A4EKC3; -.
DR   eggNOG; COG1024; Bacteria.
DR   OrthoDB; 9790967at2; -.
DR   Proteomes; UP000003535; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Isomerase {ECO:0000313|EMBL:EBA11670.1}.
FT   DOMAIN          13..332
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   347 AA;  38065 MW;  BC7B4695A3627C11 CRC64;
     MTDISIRKTG HAGHITLNRH KALNALTWDM CLAIEQALDD WRDDPDVALI LIDGAGDRAF
     CSGGDIAEMY AAGQRGDLDY GRRFWRDEYR LNAKLYNYTK PIVTFLHGFT MGGGVGVGCH
     ASHRIVCETS QIAMPECSIG LVPDVGGSLI LAKASGHCGE FLGVSGDRMD AADAIYVGFA
     DHYVPQDAWD ELKATLIKTG DLKAIESTER AAPAARLADW QDEIDACFGG ANLGDIYRAM
     PDTPGPAMTH ARKLMDRNAP LAMAVAVKTI QAARHDPHIE NALDREFRYT YRCVAQGDFI
     EGIRAAIIDR DRNPKWQHSS WDAVTAEDVA AMTRDLGKDA LQWKDKA
//