ID A4F659_SACEN Unreviewed; 137 AA.
AC A4F659;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Dolichyl-phosphate beta-D-mannosyltransferase {ECO:0000313|EMBL:CAL99533.1};
DE EC=2.4.1.83 {ECO:0000313|EMBL:CAL99533.1};
GN OrderedLocusNames=SACE_0181 {ECO:0000313|EMBL:CAL99533.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99533.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAL99533.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the GtrA family.
CC {ECO:0000256|ARBA:ARBA00009399}.
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DR EMBL; AM420293; CAL99533.1; -; Genomic_DNA.
DR RefSeq; WP_011872963.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F659; -.
DR STRING; 405948.SACE_0181; -.
DR KEGG; sen:SACE_0181; -.
DR eggNOG; COG2246; Bacteria.
DR HOGENOM; CLU_083873_4_3_11; -.
DR OrthoDB; 5193094at2; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR007267; GtrA_DPMS_TM.
DR PANTHER; PTHR38459; PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG; 1.
DR PANTHER; PTHR38459:SF1; PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG; 1.
DR Pfam; PF04138; GtrA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:CAL99533.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAL99533.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..136
FT /note="GtrA/DPMS transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04138"
SQ SEQUENCE 137 AA; 15076 MW; E440EDEB0AFC7F06 CRC64;
MTRTDPGAPV VRERLVSRSL VLYALIGCSG VLLDYGLFLL LFNLAGLHEQ LANAISTTAG
ITNNFVLNAL LNFRKRDRIL VRFLRFYAVG VAGIGLTFVL LQVFSGFLGV DPNLVKAGSL
PLVLVFQYTI NRKWSFG
//
