ID A4F7V5_SACEN Unreviewed; 440 AA.
AC A4F7V5;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Two-component system sensor histidine kinase DesK {ECO:0000313|EMBL:PFG93928.1};
DE SubName: Full=Two-component system sensor kinase {ECO:0000313|EMBL:CAM00129.1};
GN OrderedLocusNames=SACE_0788 {ECO:0000313|EMBL:CAM00129.1};
GN ORFNames=A8924_1187 {ECO:0000313|EMBL:PFG93928.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00129.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM00129.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM00129.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG93928.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93928.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM00129.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG93928.1; -; Genomic_DNA.
DR RefSeq; WP_009944287.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F7V5; -.
DR STRING; 405948.SACE_0788; -.
DR KEGG; sen:SACE_0788; -.
DR eggNOG; COG4585; Bacteria.
DR HOGENOM; CLU_000445_20_8_11; -.
DR OrthoDB; 5241784at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF63; SENSOR HISTIDINE KINASE DESK; 1.
DR Pfam; PF07730; HisKA_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAM00129.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..316
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 46847 MW; 4FC780938BA4E780 CRC64;
MPDPTDVRRP RPTGSDPTGV HPTPPTGSRR AAQPHVPARE GESTAPGEPE FNTRRILRLR
RLTWWAIVPT VPVFACVAGV FAVVAPAETG ISTIQIAALV AILVVVAVEG TRFSLGMMGG
LGKPRQHPLE QAGAFALAVA GMCYAIWLSP PNVLTWTLLP SALAGALAAA APRRFRLRLA
TGLIVLVVAV GPVSMVLAGK PELSGSVLSY SAFVSGATVF AMIFQAWVWD IVLELDRARW
VSAELAVARE RLRFAADLHD VQGHHLQAIA LKGELAERLV GVDDDAARAQ AAEVAELART
ALRDTREVVH GYRRTSLATE IDNAVAILRS ADIDTTVDGD PALVPPPLEP LFGALVREGA
TNVLRHSRAR RCELKIRSDD GRVRVVLRND GIIGGGDSAG SGIDGLRERF ATLGGQVRAA
GRDGWFELTG LADEPGRPRS
//
