ID A4F8X3_SACEN Unreviewed; 623 AA.
AC A4F8X3;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Succinate dehydrogenase / fumarate reductase flavoprotein subunit {ECO:0000313|EMBL:PFG94295.1};
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:CAM00498.1};
DE EC=1.3.99.1 {ECO:0000313|EMBL:CAM00498.1};
GN Name=sdhA1 {ECO:0000313|EMBL:CAM00498.1};
GN OrderedLocusNames=SACE_1170 {ECO:0000313|EMBL:CAM00498.1};
GN ORFNames=A8924_1566 {ECO:0000313|EMBL:PFG94295.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00498.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM00498.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM00498.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG94295.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG94295.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM00498.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG94295.1; -; Genomic_DNA.
DR RefSeq; WP_009949505.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F8X3; -.
DR STRING; 405948.SACE_1170; -.
DR KEGG; sen:SACE_1170; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_8_1_11; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAM00498.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 10..429
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 485..582
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT COILED 498..529
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 322
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ SEQUENCE 623 AA; 69026 MW; 5B2287779B3751A3 CRC64;
MVEIERHDYD VVVIGAGGAG LRAAIETRSQ GLRTAVVCKS LFGKAHTVMA EGGIAASMGN
VNSRDNWQVH FRDTMRGGKF LNNWRMAELH AKEAPDRVWE LETYGALFDR TEDGRISQRN
FGGHEYPRLA HVGDRTGLEL IRTLQQKIVS LQQEDKAEFG DYEARLKVFQ ECTVTELLKE
SGRIAGAFGY WRESGRFVQF RAPAVVLATG GIGKSFKVTS NSWEYTGDGH ALALRAGASL
INMEFVQFHP TGMVWPPSVK GILVTESVRG DGGVLRNSEG SRFMFDYIPE VFKDNYADSE
EEADRWYGDP DSNRRPPELL PRDEVARAIN SEVKEGRGSE HGGVFLDVSS RLSAEEITRR
LPSMHHQFKE LADVDITAEP MEVGPTCHYV MGGVEVEPDT AQSRVPGLFA AGEVAGGMHG
SNRLGGNSLS DLLVFGRRAG LGATKYLEGL ESRPAVRESE VDDAAQRAQI PFEPGDGAEN
PYGLHSELQQ VMNDLVGIIR KGEEMQTALE KLRELKRRAK NLAVEGNRQF NPGWHLALDL
SNMLLVSECV AAAAVLRTES RGGHTRDDHP GMDPRWRGVV LSCSLFDGGV EVTEQRQPPM
RDDLLSLFKV EELRKYFPED ELP
//
