ID A4F9B9_SACEN Unreviewed; 674 AA.
AC A4F9B9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Probable copper resistance transporter {ECO:0000313|EMBL:CAM00644.1};
GN OrderedLocusNames=SACE_1321 {ECO:0000313|EMBL:CAM00644.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00644.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM00644.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AM420293; CAM00644.1; -; Genomic_DNA.
DR RefSeq; WP_009947923.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F9B9; -.
DR STRING; 405948.SACE_1321; -.
DR KEGG; sen:SACE_1321; -.
DR eggNOG; COG1276; Bacteria.
DR eggNOG; COG3336; Bacteria.
DR HOGENOM; CLU_016803_0_0_11; -.
DR OrthoDB; 5241646at2; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR InterPro; IPR019108; Caa3_assmbl_CtaG-rel.
DR InterPro; IPR032694; CopC/D.
DR InterPro; IPR008457; Cu-R_CopD_dom.
DR PANTHER; PTHR34820; INNER MEMBRANE PROTEIN YEBZ; 1.
DR PANTHER; PTHR34820:SF4; INNER MEMBRANE PROTEIN YEBZ; 1.
DR Pfam; PF09678; Caa3_CtaG; 1.
DR Pfam; PF05425; CopD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..338
FT /note="Copper resistance protein D"
FT /evidence="ECO:0000259|Pfam:PF05425"
SQ SEQUENCE 674 AA; 70834 MW; 8DE18406900A2283 CRC64;
MASETVSDST APEARTRSSA VGVLVVTAGV LAALVAAALT ALSASDAYAA YGLPDPGPVT
RFGLPVVRVI AESGAVVCIG SLLLAAFGIP AKRSGALAAD GYAAVRAAGW AAAVWFVGAV
LMVAFTAADA SGRPVHEVLD TEVLFGLVDA LEEAKAWGLT ALIAFVLALA CRVVLTWGWT
TVLFGGSLAG LFPVIATGHS ATGGAHDIAT NSLLFHLFGA ALWVGGLVAL LAHAVRGGAH
LGLVARRYSA IALVCWIAMA ASGVINSLVR VPLDQLFSTT YGVLVTLKVL ALVALGGFGY
FQRQRAVRDI DRGSGALVRL GAVELLVMFA TIGIAVALGR TPPPAELGPV PSKTELLVGY
PLEAPPTLFR LLFDVRFDLV YGTLAIALAV LYLVGVRRLR ARGDKWPVGR TAAWLCGCAT
ILVATSAGVG KYAPAVFSVH MGQHMLMSML APPLLVLGGP TSLALRVLKP AGKGRPPGAR
EWLLAFLHSP LTRLLTNPFI ALALFVGSFY ALYFSGLFDV ALTQHWAHLA MNAHFLLVGY
VFYWPVIGVD PAPKPLPSLG KVGLVFASMP FHAFFGIALM MSATVIGQNF YRSLELPWMT
DLLADQRLGG GLAWASGEVP LIVVMLALLI QWSRADTRAA RRMDRKADAD GDAELTAYNA
MLRQMAEQDS PRKG
//
