ID A4F9H0_SACEN Unreviewed; 343 AA.
AC A4F9H0;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Beta lactamase {ECO:0000313|EMBL:CAM00695.1};
DE SubName: Full=Beta-lactamase class A {ECO:0000313|EMBL:PFG94482.1};
GN OrderedLocusNames=SACE_1373 {ECO:0000313|EMBL:CAM00695.1};
GN ORFNames=A8924_1770 {ECO:0000313|EMBL:PFG94482.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00695.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM00695.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM00695.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG94482.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG94482.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM00695.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG94482.1; -; Genomic_DNA.
DR RefSeq; WP_009950184.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F9H0; -.
DR STRING; 405948.SACE_1373; -.
DR KEGG; sen:SACE_1373; -.
DR eggNOG; COG2367; Bacteria.
DR HOGENOM; CLU_031960_3_0_11; -.
DR OrthoDB; 33989at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF4; SLR0121 PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 76..311
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
FT REGION 28..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 35740 MW; 8BD398083F3D54B0 CRC64;
MSGAEQEIRE VLRDAGAEGW VHAMPLTGAT TRVSAPAREA GPAREAWPGS GTEAGEFGPE
AGPGREGRSG SETGPGREIG IGADDLVVTA SVYKLPLVVA LCRAFDAGRI DPRARVRLNP
PSCTPGPTGL ATFLDPVTVS WRDMAASMIG VSDNTSADVI LGEVGLDAVA ETLAELGLER
TRVVGGTADS HASLVRDTGA ATAAEAFAEL FDNDAAHTVS AYDPAYASAT TPREMTRLLD
LIWSDAVASP QQCAFIRRLL SNQVWMHRVR AGFPSRGVHV AGKTGTVGAV RNEVSVVEFE
GEVPVAVAVF TLAARADAFL PKVDAAIADC ARIAVNDLRS GRL
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