ID A4FD46_SACEN Unreviewed; 449 AA.
AC A4FD46;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Anthranilate synthase component 1/salicylate synthetase {ECO:0000313|EMBL:PFG95715.1};
DE SubName: Full=Anthranilate synthase component I {ECO:0000313|EMBL:CAM01971.1};
DE EC=4.1.3.27 {ECO:0000313|EMBL:CAM01971.1};
GN Name=trpE {ECO:0000313|EMBL:CAM01971.1};
GN OrderedLocusNames=SACE_2689 {ECO:0000313|EMBL:CAM01971.1};
GN ORFNames=A8924_3077 {ECO:0000313|EMBL:PFG95715.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM01971.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM01971.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM01971.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG95715.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG95715.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AM420293; CAM01971.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG95715.1; -; Genomic_DNA.
DR RefSeq; WP_009947642.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FD46; -.
DR STRING; 405948.SACE_2689; -.
DR KEGG; sen:SACE_2689; -.
DR eggNOG; COG0147; Bacteria.
DR HOGENOM; CLU_006493_2_1_11; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR019996; Salicylate_synthase.
DR NCBIfam; TIGR03494; salicyl_syn; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF48; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CAM01971.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 180..433
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 449 AA; 48522 MW; 461ABC7B82FAC757 CRC64;
MGAPTVSRRN YDETTLPLST DPLLAAARLA ESGLSDTFVL YEREGQWCLG IGVLCEITVD
TSTVVMNTAD GERRCESWIG SPLDVVGELL QDVPAAQWRA YGWAGFELAY AHAGLLEDGE
DHTLLHLVVP HTEVVLETGR ATVRSTEQAF LDKAVELLGS PPEEPGYQPM PIEVGDSGFE
EYGQAVASAV DDIRDGLLQK VILSRVVPVD QPVDLVGTYV VGRRRNTPAR SFLLNAGGLR
AAGFSPEIVM THEAGGRVTT QPLAGTRALT GRAGEDERVR ADLLNNSKEI FEHAISVKVA
YDELVELCDE DNVTVDSFMT VSERGSVQHL ASSVSGQLLE HQGPWQALAA LFPAVTASGV
PKKAAYECIR RYEPEERGLY SGAVLTVDHA GTMDAALVLR TVFQQDGRTW LRAGAGIVGQ
SEPEREFEET CEKLRSVALH LVPPQGSSS
//
