ID A4FDX1_SACEN Unreviewed; 385 AA.
AC A4FDX1;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:CAM02246.1};
DE SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase II {ECO:0000313|EMBL:PFG95976.1};
GN OrderedLocusNames=SACE_2968 {ECO:0000313|EMBL:CAM02246.1};
GN ORFNames=A8924_3360 {ECO:0000313|EMBL:PFG95976.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02246.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02246.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM02246.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG95976.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG95976.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; AM420293; CAM02246.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG95976.1; -; Genomic_DNA.
DR RefSeq; WP_009949640.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FDX1; -.
DR SMR; A4FDX1; -.
DR STRING; 405948.SACE_2968; -.
DR KEGG; sen:SACE_2968; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..382
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 385 AA; 40267 MW; ED0D77ABA2049438 CRC64;
MQHCGIGGIG AVTGYGWGRE SFWNGLVSGE VAASPVERHG PGRDRTAWVA KVPEGGEEAD
GPSRFAKAMR AAAREAIVDA EERGWRPGRR VGLLHAAVLG DLPSWNDFYG RRGGDVPVRD
YLALMPSTPV SMLMQEFGFH GPAMNVSATC ASGNAGLLTA KAWLDAGVVD DVVFVATDVS
STPETVLHFE RLGVAVTDTE PRQACRPFQE GSRGFVMGEA SVGMVLSSGG TGHYARVLGG
AMSHDAHHVT SVDPDAAELR RCFTEALADA GADPSRVRYL NAHGPGTRQC DRAESGVFDE
LFPAEARLYS VKPLVGHCMG AASAVEVAAA ALGYDRGIIP APQPVAEGHP RLLDGPTPQA
DGLTLKSSLG LGGHNSAVVL APADR
//
