ID A4FE29_SACEN Unreviewed; 544 AA.
AC A4FE29;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 102.
DE SubName: Full=Transcriptional activator of the SARP family {ECO:0000313|EMBL:CAM02304.1};
GN OrderedLocusNames=SACE_3026 {ECO:0000313|EMBL:CAM02304.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02304.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02304.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; AM420293; CAM02304.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FE29; -.
DR STRING; 405948.SACE_3026; -.
DR KEGG; sen:SACE_3026; -.
DR eggNOG; COG1396; Bacteria.
DR eggNOG; COG3629; Bacteria.
DR HOGENOM; CLU_500456_0_0_11; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR043917; DUF5753.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF19054; DUF5753; 1.
DR Pfam; PF13560; HTH_31; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 1..88
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DOMAIN 281..335
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DNA_BIND 1..88
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 185..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 59493 MW; AB873E373BE38D1E CRC64;
MEVVSDGRPV PLGDRRRRAV LGHLLLHANQ VVHTDRLAQA VQGDDLTGDA QKRVHNTISQ
LREVLVPQSG AAPGPALRTH LAGYLLRVDP DAVDLLRFRD LAERGRAELA AGAWEAPADR
LREARELWRG PVLADLADEF PWPELTGIRH ERLDALEDHF EAELACGRPT PLVPELRELV
RAEPGRERLQ RRLKRALSAS GNESGVPARQ VAAATGCTGE PESHKLPVAG RTLSKPATSP
PRSTPDTADR TPVALVPQQR RSADDQPAVP SGAPSGVAAE LRRLRIAAGL TGERLSARAR
MSQSKISKIE NGRQPASPGD VERLLLALDA SPATVTELLG LCGPATAEPR ATCPRQGGHE
PSRPSELITR SKLIRHALTS MLPGCLQIPE YRRRNAESPL ARAGGRSRTE PSNRELDEQR
ALFHSDKHFH FLLTEAAVRC QVTSPRAMAV QVDHLVSVGM MPNADIAVLP QDVPLTNPLL
NVFAVYDERL VVVRTHARET AHRDRASVVL HLELFDHLRQ RALRGGDALD FLRRVAADFR
GRSS
//
