ID A4FEE8_SACEN Unreviewed; 395 AA.
AC A4FEE8;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Ferredoxin reductase {ECO:0000313|EMBL:CAM02423.1, ECO:0000313|EMBL:PFG96148.1};
DE EC=1.18.1.3 {ECO:0000313|EMBL:CAM02423.1};
GN Name=fprC {ECO:0000313|EMBL:CAM02423.1};
GN OrderedLocusNames=SACE_3145 {ECO:0000313|EMBL:CAM02423.1};
GN ORFNames=A8924_3536 {ECO:0000313|EMBL:PFG96148.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02423.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02423.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM02423.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG96148.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96148.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; AM420293; CAM02423.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG96148.1; -; Genomic_DNA.
DR RefSeq; WP_009945265.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FEE8; -.
DR STRING; 405948.SACE_3145; -.
DR KEGG; sen:SACE_3145; -.
DR eggNOG; COG0446; Bacteria.
DR HOGENOM; CLU_003291_4_0_11; -.
DR OrthoDB; 4475657at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0008860; F:ferredoxin-NAD+ reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF2; RIESKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000313|EMBL:PFG96148.1};
KW Oxidoreductase {ECO:0000313|EMBL:CAM02423.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 4..298
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 322..387
FT /note="Reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14759"
SQ SEQUENCE 395 AA; 41825 MW; ACDA06F3C1CBC631 CRC64;
MRTITVVGAS LGGYSAAQQL RAQGFDGRLV VVGTEVHLPY DRPPLSKDFL KGRIGAADLA
LGEQQDFDEL EAEWRLGEFA ARLRPADAGI ELYSGEQIGT DGVVIATGAS TRVLPGSAGV
GGVHTLRTLE DAQALREELT TGRPNVVVIG AGFIGAEVAS SCAELGLDVT IVEAAELPLA
RVLGTRLASA CAALHSEHGV AVRFGAGVEE LRSAAGHVVG VRLSTGEELP ADVVVAGIGV
QPNTGWLSGS GLSLHDGVLC DSGGVTDLSN VVAVGDVARV FRPDLGRNVR TEHWATANGQ
PRIAVRNLLD GITNEQHTDM PYFWSDQYGV RIQFAGFVHP EDEVRILDGD IEDRCFLAQY
ERDGRPVGVL AFNHPRGFGR ARRQLSRPTL DVATS
//
