ID A4FEL2_SACEN Unreviewed; 388 AA.
AC A4FEL2;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=DegT/DnrJ/EryC1/StrS aminotransferase family protein {ECO:0000313|EMBL:CAM02487.1};
GN OrderedLocusNames=SACE_3212 {ECO:0000313|EMBL:CAM02487.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02487.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02487.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SIMILARITY: Belongs to the DegT/DnrJ/EryC1 family.
CC {ECO:0000256|RuleBase:RU004508}.
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DR EMBL; AM420293; CAM02487.1; -; Genomic_DNA.
DR RefSeq; WP_011873961.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FEL2; -.
DR STRING; 405948.SACE_3212; -.
DR KEGG; sen:SACE_3212; -.
DR eggNOG; COG0399; Bacteria.
DR HOGENOM; CLU_033332_7_2_11; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR CDD; cd00616; AHBA_syn; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000653; DegT/StrS_aminotransferase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR30244:SF36; 3-OXO-GLUCOSE-6-PHOSPHATE:GLUTAMATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR30244; TRANSAMINASE; 1.
DR Pfam; PF01041; DegT_DnrJ_EryC1; 1.
DR PIRSF; PIRSF000390; PLP_StrS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:CAM02487.1};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR000390-2,
KW ECO:0000256|RuleBase:RU004508};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAM02487.1}.
FT ACT_SITE 190
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000390-1"
FT MOD_RES 190
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000390-2"
SQ SEQUENCE 388 AA; 41593 MW; 81C9F58A982587BF CRC64;
MRALEPVPFF SQAASFESAW ALIRERIGAV FDNGKFSHGA QVAEFEEALA AYTGARYAIG
VNSGTDALVL LLRACGLRPG DEVVVPAFSF VATASSVVLA GGRPRFADID PATYALDPAE
VDRRAGPDSR FVLPSHLFWQ MADMTGLAEA AAAHDLTVVE DSAEGIGMRQ GGVHAGLHGA
GGVLSFFPSK TLGAIGDAGA VLTDDPEVAE LVSGLRHHGR LGRTLDNFPG ISTETALPGM
NSKMDDIQAA VLLAKMTFLD RDIARRAMLA EAYRQRLRDM PGIVRIPESA ERGPGSNTVF
YVYLIEVERR DELVEHLTWR GIGTETYYPV PLHLQPCFAE LGHAEGDFPH AEAACSRAVA
LPLYPDLGVD QVDRVCEAIG EFCTGRNA
//
