ID A4FEQ8_SACEN Unreviewed; 230 AA.
AC A4FEQ8;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Thioesterase involved in non-ribosomal peptide biosynthesis {ECO:0000313|EMBL:CAM02533.1};
DE EC=3.1.2.14 {ECO:0000313|EMBL:CAM02533.1};
GN OrderedLocusNames=SACE_3258 {ECO:0000313|EMBL:CAM02533.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02533.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02533.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SIMILARITY: Belongs to the thioesterase family.
CC {ECO:0000256|ARBA:ARBA00007169}.
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DR EMBL; AM420293; CAM02533.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FEQ8; -.
DR STRING; 405948.SACE_3258; -.
DR KEGG; sen:SACE_3258; -.
DR eggNOG; COG3208; Bacteria.
DR HOGENOM; CLU_070456_1_2_11; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0016297; F:acyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR012223; TEII.
DR InterPro; IPR001031; Thioesterase.
DR PANTHER; PTHR11487:SF0; S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN; 1.
DR PANTHER; PTHR11487; THIOESTERASE; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CAM02533.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 2..224
FT /note="Polyketide synthase thioesterase"
FT /evidence="ECO:0000259|SMART:SM00824"
SQ SEQUENCE 230 AA; 25109 MW; 85A1AA510643A77E CRC64;
MVCFPHAGGS ASSYLQLSKE LSSSLEVFAV QYPGRQDRRG EPGFASMTAL AERIAEVITP
LLDRPFAFFG HSMGAIAAFE VARLLEARGG GTPRALFASG RRAPTTSRDE SVHKRDDKGL
IDEIRQLSGT DSRLFDDEEI VQMILPSLRS DYTAIETYEY RPGPDVSCPI VALAADADPR
VTIEEAQQWK QHTADVFHLE TFRGGHFYLN DQVPQVARTV TAHLGAAAGG
//
