ID A4FFR1_SACEN Unreviewed; 339 AA.
AC A4FFR1;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:CAM02886.1};
DE EC=3.5.4.4 {ECO:0000313|EMBL:CAM02886.1};
GN Name=add {ECO:0000313|EMBL:CAM02886.1};
GN OrderedLocusNames=SACE_3612 {ECO:0000313|EMBL:CAM02886.1};
GN ORFNames=A8924_4005 {ECO:0000313|EMBL:PFG96604.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM02886.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM02886.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM02886.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG96604.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96604.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR EMBL; AM420293; CAM02886.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG96604.1; -; Genomic_DNA.
DR RefSeq; WP_009949013.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FFR1; -.
DR STRING; 405948.SACE_3612; -.
DR KEGG; sen:SACE_3612; -.
DR eggNOG; COG1816; Bacteria.
DR HOGENOM; CLU_039228_7_1_11; -.
DR OrthoDB; 105475at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01430; aden_deam; 1.
DR PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CAM02886.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 8..320
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 339 AA; 36624 MW; 2A15A2C7E05B9669 CRC64;
MRDPALLPKA HLHVHLESTV RWDTLRELGR ANGVAVPDRP AGFTGFRQFA DHNSLVRHCL
VRPADFTRVA REFCHDEAAQ GTRYAEVTFT AASHGERLGA PEMPLEAVLE GLALGQAETG
LRCRVLLDHS RRRSVRRAWR TLHLATRYDE VAGIGMAGEE SYPLEPFADV LDAARDAGVA
LVHHAGEACG ADSIREAIHT GHAQRIGHGI RVLDDPALTA EIRDRGIALE VCPSSNVLLG
FAASPDAHPL AHMRAAGLAV TVNTDIPAIA GTTLTDEYAL VRDTFGYDDH DLAALARTAV
QACFADEQTK RDLHHGIDAW LAAPAADTSV HNGSDITVR
//
