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Database: UniProt
Entry: A4FGV2_SACEN
LinkDB: A4FGV2_SACEN
Original site: A4FGV2_SACEN 
ID   A4FGV2_SACEN            Unreviewed;       517 AA.
AC   A4FGV2;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:CAM03277.1};
DE            EC=1.1.1.157 {ECO:0000313|EMBL:CAM03277.1};
GN   Name=paaH2 {ECO:0000313|EMBL:CAM03277.1};
GN   OrderedLocusNames=SACE_4006 {ECO:0000313|EMBL:CAM03277.1};
GN   ORFNames=A8924_4394 {ECO:0000313|EMBL:PFG96981.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748
OS   / NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03277.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM03277.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM03277.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N.,
RA   Dickens S., Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG96981.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96981.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAM03277.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG96981.1; -; Genomic_DNA.
DR   RefSeq; WP_009946708.1; NZ_PDBV01000001.1.
DR   STRING; 405948.SACE_4006; -.
DR   EnsemblBacteria; CAM03277; CAM03277; SACE_4006.
DR   KEGG; sen:SACE_4006; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000141500; -.
DR   KO; K00074; -.
DR   OMA; MGAFELT; -.
DR   OrthoDB; 862072at2; -.
DR   BioCyc; SERY405948:SACE_RS19440-MONOMER; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006728,
KW   ECO:0000313|Proteomes:UP000225825};
KW   Oxidoreductase {ECO:0000313|EMBL:CAM03277.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN       11    189       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      192    289       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      417    499       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   517 AA;  54682 MW;  FEE0D26C625A515E CRC64;
     MGQWAQQVNV VRVIGTGVMG RGIAQLAAAA GLTVELADAR QEAVSAAVDH VGEMFGKLVG
     KGRMSAEEAD AATARLRPVG DPLAPADSCD LVVEAVREDL DTKRELFAGL EEVCPRHAVL
     ATNTSSLSVT AIGAALADPS RLIGLHFFNP VPLMKLVEVI PGARTRQDLS ADLVELVRRL
     GHQPVLATDT PGFLVNHAGR GLATEALQIM SESAVEPSDV DRIARDVLGL RMGPFELLDL
     TGLDVSHPVL ESIWSGFYGD PRLRPSGITR SRLEAGLLGR KTGEGFYRYI DGVKQEAPEP
     GAPDAPRRPV WVDDTEPASR DRLVSLLREA GVVVEEEPSE DAVLLVTPYG QSAAQVARSR
     GLPVHRVFGV DPLGDFASRL VLAVHPAADV SAAASAHVAL SATGLPVTVV ADAPATIAQR
     LLASIVNTAC GIAEQRIGRP ADIDTAVRVG LGYPRGPLEW GEHAGRERIL AILRNMHAET
     GDPRYRPSRW LVERAELGLA LTGTGTTPAE VLGGGED
//
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