ID A4FGV6_SACEN Unreviewed; 440 AA.
AC A4FGV6;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:PFG96985.1};
DE SubName: Full=Metabolite transporter, MFS superfamily {ECO:0000313|EMBL:CAM03281.1};
GN OrderedLocusNames=SACE_4010 {ECO:0000313|EMBL:CAM03281.1};
GN ORFNames=A8924_4398 {ECO:0000313|EMBL:PFG96985.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03281.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03281.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM03281.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG96985.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG96985.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AM420293; CAM03281.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG96985.1; -; Genomic_DNA.
DR RefSeq; WP_009946703.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FGV6; -.
DR STRING; 405948.SACE_4010; -.
DR KEGG; sen:SACE_4010; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_39_5_11; -.
DR OrthoDB; 9066401at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17369; MFS_ShiA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR43045:SF2; INNER MEMBRANE METABOLITE TRANSPORT PROTEIN YHJE; 1.
DR PANTHER; PTHR43045; SHIKIMATE TRANSPORTER; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..423
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 440 AA; 46841 MW; 4FAEA374F2F8E4DA CRC64;
MSQAVPDTRV ARRAGIASFT GTTIEWYDFY IYSSASALVL NKVFFPTVDP AAGTLAAFAT
FWVGFLARPV GGVLFGHLGD RIGRKKTLIT TLLLMGGATT CVGLLPTYAT IGVAAPLLLV
VLRMLQGVAM GGEWGGAVLI ASEHAPKGRK ILYGAFAQQG SPAGNVLATL SFLLVAQLPD
EAFSSWGWRI PFLASALLVV VSLVIRLSVE ESPEMRRLME SRTVAKLPIR DVLRSSPLII
ALGVGACTIA VSATYFKSTF ALSWAVSDLG FQRSTFLTVI LVAGIAQLIF QPLGAVLATR
WDLRRAVTVL LVPELVLMPA MFWLISTGSL GLSMLGMAVA TLPHAMYYAA LAGILARSFP
AHVRYTGISL CYQLCTTLFA GTAPMLGQYL MNVTGSIVSV VFLAVAHVLL TLFCVLALLR
RAPSTEGEPV AERPVVARSA
//
