ID A4FH41_SACEN Unreviewed; 438 AA.
AC A4FH41;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Nucleoside-diphosphate sugar epimerase (SulA family) {ECO:0000313|EMBL:CAM03366.1};
GN OrderedLocusNames=SACE_4096 {ECO:0000313|EMBL:CAM03366.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03366.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03366.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. SDR39U1 subfamily. {ECO:0000256|ARBA:ARBA00009353}.
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DR EMBL; AM420293; CAM03366.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FH41; -.
DR STRING; 405948.SACE_4096; -.
DR KEGG; sen:SACE_4096; -.
DR eggNOG; COG1090; Bacteria.
DR eggNOG; COG4276; Bacteria.
DR HOGENOM; CLU_047373_4_0_11; -.
DR Proteomes; UP000006728; Chromosome.
DR CDD; cd07820; SRPBCC_3; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013549; DUF1731.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010099; SDR39U1.
DR InterPro; IPR023393; START-like_dom_sf.
DR NCBIfam; TIGR01777; yfcH; 1.
DR PANTHER; PTHR11092:SF0; EPIMERASE FAMILY PROTEIN SDR39U1; 1.
DR PANTHER; PTHR11092; SUGAR NUCLEOTIDE EPIMERASE RELATED; 1.
DR Pfam; PF08338; DUF1731; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 144..348
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 384..432
FT /note="DUF1731"
FT /evidence="ECO:0000259|Pfam:PF08338"
SQ SEQUENCE 438 AA; 47572 MW; 2DD7A1B2B5BBD95D CRC64;
MIDAPVDEVF AWHGRPGAIT RLTPPWGPAR VVAESGSLRD GQAVLALPGG MRWVAQHDPA
AYDPPRRFVD ELASPLLRPA IRWRHTHEFS EAGDGTTRLT DTVETTVPAR ALRPMFAYRH
RQLADDLAAH RWAREHRPEP LTVAVSGSSG VVGTALTALL TTGGHRVVRL VRRTPRAQDE
RWWDPEAPAG DLLDGVDAVV HLAGASIAGR FTAEHKRRIR ESRVGPTARL SELAARTGTG
TFVTASAIGC YGFDRGDETL TEESPRGDGF LADVVEDWES AAEPARAAGA RVVHVRTGIV
QTAAGGVLRL MHPLFAAGLG GPLGSGEQWT SWIGIDDLLD VYYRALVDDR LRGPVNAVAP
NPVRNREYSR ILGRVLRRPA LLPTPSLAPR AVLGEEGARE LALAGQRVVP LRLLAVRHPF
RFRDLEPALR HALGRTAS
//
