ID A4FHM1_SACEN Unreviewed; 326 AA.
AC A4FHM1;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Oleandomycin transport system ATP-binding protein {ECO:0000313|EMBL:PFG97236.1};
DE SubName: Full=Probable ABC transporter, ATP-binding component {ECO:0000313|EMBL:CAM03546.1};
GN OrderedLocusNames=SACE_4277 {ECO:0000313|EMBL:CAM03546.1};
GN ORFNames=A8924_4666 {ECO:0000313|EMBL:PFG97236.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03546.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03546.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM03546.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG97236.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG97236.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM03546.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG97236.1; -; Genomic_DNA.
DR RefSeq; WP_011874291.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FHM1; -.
DR STRING; 405948.SACE_4277; -.
DR KEGG; sen:SACE_4277; -.
DR eggNOG; COG1131; Bacteria.
DR HOGENOM; CLU_000604_1_2_11; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CAM03546.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 5..235
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 326 AA; 35715 MW; C5611CDF7E6A77F6 CRC64;
MTAAVQVEGL VKRFGERRVV DGVDLTIPEG TVLGLLGPNG AGKTTTVRML STLIRPDGGR
ARIGRYDLVK QANQVRRLIG LTGQYASVDE GISGRENLYM IARLLDLPRK RAWARVDELL
EQFDLVEAAS RPAGKYSGGM RRRLDLAASM VGDPAVLYLD EPTTGLDPRS RNNLWDSVRA
LVDEGTTVLL TTQYMEEAEA LADSVVVMDQ GRVIASGTSS ELRARVGGQV LRVRTAGQEH
LDQLARRLTA MRARNFRVDA ENSLVSVPIV NESELTEVIH MLAASRLPIS GVDTHLPSLD
EVFLTLTDKP HRPADPDATV VLRRVF
//
