ID A4FHW4_SACEN Unreviewed; 710 AA.
AC A4FHW4;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:PFG97324.1};
DE SubName: Full=Sensory box protein {ECO:0000313|EMBL:CAM03639.1};
GN OrderedLocusNames=SACE_4370 {ECO:0000313|EMBL:CAM03639.1};
GN ORFNames=A8924_4757 {ECO:0000313|EMBL:PFG97324.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03639.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03639.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM03639.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG97324.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG97324.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM03639.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG97324.1; -; Genomic_DNA.
DR RefSeq; WP_009942840.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FHW4; -.
DR STRING; 405948.SACE_4370; -.
DR KEGG; sen:SACE_4370; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_20_11; -.
DR OrthoDB; 9764154at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 32..89
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 141..196
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 299..432
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 443..696
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT REGION 190..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 77743 MW; 131DFBAFC0C48F05 CRC64;
MYPEQSGGPH DHGVQASAAK VLAAEDMREY AIFSLDASGR VASWNAGAQR VKGYRSEEII
GKDFSVFYPH ELAESGYPQW ELEQAAQDGF FIDRGWRVRK DGSRFWAHVV ITAQRSPDGV
LDGFIKVTRD ESTAQVREHS SRRQFTDLFE LASTGIALFD DAGRLLDANV ALTDLLACPL
PQLRDKMDRD FLHPSDEGNG GLLPSTSPLR SPGGVGGPIP HRVLTTSEGE PVLCQVHSKA
SVDAEGGRSW LAIFHDVTEQ VRRTEVLSFQ ATHDGTTGLL NRRGFEEVLS SLLSPEADGE
VAVLFCDLDN FKRVNDALGH EAGDELLAAV ADRLTTELPP KCTAARFYAD QFVIVCPDVD
AVGGSDALTK HVGNVFRMVV PLREWRVHVS ASVGSTVVED HGTSITEILR LAEAAMIENR
FRSHGRLQLV QSSSRPAEPH TDQLTLEHHL REALADDRID LHYQPIIDND GAVVMAEALL
RWSDPELGPV TPDVALGVAE RGGLLTGLDR CVLRKALHTS VGLRRPDGRP IAVAVNLSGL
HPDRPEFVEE VLAAVDEAGA DPENLVLEMV ETVLAELGPT PQRAVRRLVD AGVRFAMDDF
GTGYSSLARL RELPTQILKL DRLFVGQVCF DPANLGITRA VAELARTMRR QCIAEGVENA
TQHHLLRAIG IDAYQGYYFS PPLPPDDFRD FLATTPIQTP QTLDPHSPEV
//
