ID A4FIQ7_SACEN Unreviewed; 337 AA.
AC A4FIQ7;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:PFG97607.1};
DE SubName: Full=Transcriptional regulator, LacI family {ECO:0000313|EMBL:CAM03932.1};
GN OrderedLocusNames=SACE_4663 {ECO:0000313|EMBL:CAM03932.1};
GN ORFNames=A8924_5049 {ECO:0000313|EMBL:PFG97607.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM03932.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM03932.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM03932.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG97607.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG97607.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM03932.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG97607.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FIQ7; -.
DR STRING; 405948.SACE_4663; -.
DR KEGG; sen:SACE_4663; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_1_11; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF121; HTH-TYPE TRANSCRIPTIONAL REPRESSOR CYTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..62
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 337 AA; 35224 MW; 1C5AFA51E29FB544 CRC64;
MAGKAGKTTI VDVAREAGTS VSSASVALRG EPGVSDRTRA RILDAAQRLG YRPDQRARLL
RQQRSRLLGV TFSVDQSFHA DVIENLYRAA EGTGYGLLLS ATAPNRPARE AIADLLRDRC
ETLILVSPDL SAEQLAEVGA LASVVSVGAG VRADGVDSVR SDDHQGVVDA VAHLVGLGHR
SITYVDGGCA VMSAIRRDAY VEAMGAHGLG DQVRVLHGSP TEESGVEVAG RLLDGAEPLP
TAILAHNDMI AFGLLLTLWS RSVAVPGEIS VVGYDNTRMA ALATVRLTSV SQDAAQLARA
AVERAIARTE NAVVATETVT PARLVVRETS GPPRGGA
//
