ID A4FJI1_SACEN Unreviewed; 491 AA.
AC A4FJI1;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Fructuronate reductase {ECO:0000313|EMBL:CAM04206.1};
DE EC=1.1.1.57 {ECO:0000313|EMBL:CAM04206.1};
GN OrderedLocusNames=SACE_4940 {ECO:0000313|EMBL:CAM04206.1};
GN ORFNames=A8924_5324 {ECO:0000313|EMBL:PFG97866.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04206.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM04206.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM04206.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG97866.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG97866.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM04206.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG97866.1; -; Genomic_DNA.
DR RefSeq; WP_011874519.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FJI1; -.
DR STRING; 405948.SACE_4940; -.
DR KEGG; sen:SACE_4940; -.
DR eggNOG; COG0246; Bacteria.
DR HOGENOM; CLU_027324_0_1_11; -.
DR OrthoDB; 271711at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0008866; F:fructuronate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR000669; Mannitol_DH.
DR InterPro; IPR013118; Mannitol_DH_C.
DR InterPro; IPR023027; Mannitol_DH_CS.
DR InterPro; IPR013131; Mannitol_DH_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43362:SF1; MANNITOL DEHYDROGENASE 2-RELATED; 1.
DR PANTHER; PTHR43362; MANNITOL DEHYDROGENASE DSF1-RELATED; 1.
DR Pfam; PF01232; Mannitol_dh; 1.
DR Pfam; PF08125; Mannitol_dh_C; 1.
DR PRINTS; PR00084; MTLDHDRGNASE.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CAM04206.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 25..184
FT /note="Mannitol dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01232"
FT DOMAIN 215..408
FT /note="Mannitol dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08125"
SQ SEQUENCE 491 AA; 51886 MW; F0E4947FA11A06AC CRC64;
MTQPLGRKSL LAGSRLGASA PDRTGIVHLG LGNFHRAHGA VYTAQAMAAA GGDWGIRGFA
HSSDRVVAPM RAQDNVYSIL QLTERGAEAG LVDVHRDTGV AAQDPAAVVD AIADPAHRIV
SLTVSEVGYT RDPATGRLAL DAPEVAADLT AGSTPRTAVG MIARGLEQRA ASGEPFAVLS
CDNLQSAGDV TRAVVEEFLQ AAGVSDDVLS FVSSSVSFPN GMVDRIVPRT TDEHSRIVAD
LLGVQDLCPV PAEEFTMWVL EDDFAGGRPA WDLAGATFSN EIEAYEMVKL RLLNGSHSLI
AYLGILSGAP TIDVAWGQDF VREAVLNGIT DDYLPTFTPP TGFDADAYVS ELDARWRNPL
IGHATTQVGT DGSLKLLQRI PNAALFHLRR GDMPHHLALC IAAWIACVAP PAGFTPEPLA
ERIVEPARDR LAAAVDGAVT VADHVRRIMN GGFFPDALAE QDAFTVRVAD LLTLVVRDGV
RAAAADVAAS R
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