ID A4FK89_SACEN Unreviewed; 856 AA.
AC A4FK89;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative flippase GtrA {ECO:0000313|EMBL:PFG98104.1};
GN OrderedLocusNames=SACE_5224 {ECO:0000313|EMBL:CAM04464.1};
GN ORFNames=A8924_5604 {ECO:0000313|EMBL:PFG98104.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM04464.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM04464.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM04464.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG98104.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG98104.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the GtrA family.
CC {ECO:0000256|ARBA:ARBA00009399}.
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DR EMBL; AM420293; CAM04464.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG98104.1; -; Genomic_DNA.
DR RefSeq; WP_009942393.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FK89; -.
DR STRING; 405948.SACE_5224; -.
DR KEGG; sen:SACE_5224; -.
DR eggNOG; COG2246; Bacteria.
DR HOGENOM; CLU_021958_0_0_11; -.
DR OrthoDB; 3752109at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR InterPro; IPR007267; GtrA_DPMS_TM.
DR PANTHER; PTHR38459; PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG; 1.
DR PANTHER; PTHR38459:SF1; PROPHAGE BACTOPRENOL-LINKED GLUCOSE TRANSLOCASE HOMOLOG; 1.
DR Pfam; PF04138; GtrA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..126
FT /note="GtrA/DPMS transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04138"
SQ SEQUENCE 856 AA; 91827 MW; 3BD94BC1B6566747 CRC64;
MVWGDAARST LVGSGFVRFA AVGVANTAVH CAAYLASWVV LPYVVAHVVA TVTAMLCSYV
LNCRFTFGVV PRARTLLLYP LSNVPTIALS AGVVAVLVGV FGVGPVVAPV LGGLLVLPVT
FLLSKRALTC APTPAAAASL TWRARFHARK PEIRAAVAVA ALVAVLAQIP ALVNPSFYFW
DDSAAQFLPM WHRLGERLLA GEWPLLLDAD AWMGGNLAAE ALFGVWNPLH LLDYLLVVAI
GDLAVAATAI KTQFLVVLGV GVHALCRGYG ASRAAASVLA TALPVSGFVL YFQASSWAAG
LMGFAWVPWV WWSLRRMADG RAAPWVVWVF CFLCVSAGDP YGVLAMCAIF GAVLVETALA
GKPVARLAGV GAAAALTLPL VFLPLVMTGP VTWRSGLELF NVGQLVPDIA DLLNASMPGF
APQILSFGSF RMTVPATYLA WFVVPLLPWL NWRAALAHRR RCCAALVLAG FYALLCLGPS
NAWLFRWPLR HVAVLWLAVS VLFAVALSHG LRTDRLRVRL TCTAAALAGS AYLSFAAWPS
QSLKHLASLV VICGLLVVVL ASRTSASRAV VIHLGTACAL VMQMWWFPAN RDVATYNFPT
DVDRVRAEFA DVRGGTLFQI ADRNAISGED VESGRAWRRL LFGHMHAVAE VPSLVSYTGI
GYEPLHRRLC LSYYGSACAE AYRRLWKADE TGAVLADQLR LDRVVVQRKL IDDPEPPPGW
QVSERAPDVV VLRRQGSLPW REGRLSVAHG VTVSGSVQDG QRAETVRFRA ARSSGAELVF
ARLAWPGYSA TVDGVPTAVR STSAGLLKVV LPRGAEAGTL RVTWQPPWFG LQAVLAALGA
ALAVVLSTRT RRAEPC
//
