ID A4FNH2_SACEN Unreviewed; 497 AA.
AC A4FNH2;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Two-component sensor histidine kinase {ECO:0000313|EMBL:PFG99235.1};
DE SubName: Full=Two-component system sensor kinase {ECO:0000313|EMBL:CAM05597.1};
GN OrderedLocusNames=SACE_6427 {ECO:0000313|EMBL:CAM05597.1};
GN ORFNames=A8924_6774 {ECO:0000313|EMBL:PFG99235.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM05597.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM05597.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM05597.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG99235.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG99235.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAM05597.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG99235.1; -; Genomic_DNA.
DR RefSeq; WP_009949682.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FNH2; -.
DR STRING; 405948.SACE_6427; -.
DR KEGG; sen:SACE_6427; -.
DR eggNOG; COG3920; Bacteria.
DR HOGENOM; CLU_045351_1_0_11; -.
DR OrthoDB; 9767435at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.280; GAF domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR038424; H_kinase_PdtaS_GAF_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR022066; PdtaS_GAF.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF23; SENSOR HISTIDINE KINASE PDTAS-RELATED; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF12282; PdtaS_GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAM05597.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAM05597.1}.
FT DOMAIN 300..495
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 497 AA; 54287 MW; 3AE881204A6EB307 CRC64;
MSTLSDLLAE HTGLSGAAAD HLQLVVAEWQ LLSDLSFADF LMWVPIGPPD AAESRFLCVA
QARPTTAPTA HPEDVVGSEV TQDEHPQLRR AAVEGRICRE EDPRWHLGVP VRRETIPVKL
GREIVAVLSR DTNLAVPRVP SPLEISYLGS AADLCQMVAD GTFPTPEPSP DVHTSPRVGD
GLIRLDASGS VVFASPNALS AYHRMGHASD LVGAQLAPLT RSLLTDPFDA DEVSQRIRRA
NGGQPSMRME ADARGATVLF RALPLHPRGQ QAGALVLVRD VTEVKRRDRA LLSKDATIRE
IHHRVKNNLQ TVAALLRLQS RRTGNSEARL ALEESVRRVT SIALVHETLS MSVDERVDLD
DVVDRVIPMM SDVAAAETGV KVRRDGRFGV VSAELATPLV MVLTELVQNA FEHAFPEGQG
GEVVVQAERS ARWLDVVISD DGRGLPKGFS LERAERLGLQ IVRTLVESEL RGSLSLRGRG
RQRGTEAVLR VPLKYRR
//
