ID A4FV07_BOVIN Unreviewed; 494 AA.
AC A4FV07;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=UBASH3A protein {ECO:0000313|EMBL:AAI23554.1};
DE SubName: Full=Ubiquitin associated and SH3 domain containing A {ECO:0000313|Ensembl:ENSBTAP00000057079.1};
GN Name=UBASH3A {ECO:0000313|EMBL:AAI23554.1,
GN ECO:0000313|Ensembl:ENSBTAP00000057079.1,
GN ECO:0000313|VGNC:VGNC:36574};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI23554.1};
RN [1] {ECO:0000313|EMBL:AAI23554.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI23554.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:AAI23554.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000057079.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057079.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000057079.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057079.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC123553; AAI23554.1; -; mRNA.
DR Ensembl; ENSBTAT00000085998.1; ENSBTAP00000057079.1; ENSBTAG00000023398.5.
DR VEuPathDB; HostDB:ENSBTAG00000023398; -.
DR VGNC; VGNC:36574; UBASH3A.
DR GeneTree; ENSGT00940000160841; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000023398; Expressed in oocyte and 80 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR CDD; cd11937; SH3_UBASH3A; 1.
DR CDD; cd14300; UBA_UBS3A_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR035634; UBASH3A_SH3.
DR PANTHER; PTHR16469; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED; 1.
DR PANTHER; PTHR16469:SF7; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN A; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 19..60
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 238..303
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 319..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 55697 MW; 548BAF432BE71E8E CRC64;
MAAGETQLYA KVFNKLKGRS TPSLLDPLLG MGFPAHTALK ALAATGRKTA EEASNWLHCH
CNDPSLDDPI PQEYALFLCP TGPLLDKLQD FWRESRRQCA KNRAHEVFPH ITLCDFFTCE
DQKVEYLYEA LKRAGDRTLR AFPSAVPLVL HSSISYLGFF VDDSPADIIR EFAVMFATEA
SVLADCTVKP CTKQLHLTLA HKFYPHHQRT LEQLARAINP SHSCQWTATL YSRDMRFVHY
QTLRVLFQYK PQNVDELTLS PGDYIFVDPT QQEEASEGWV IGISQRTGCR GFLPENYTER
ASECDTWVRH RTYTFSVTPD LSSRKDGEAS SRRNGDPNPP SSSRSLSSLQ SLQATIVRRS
VLVVRHGERV DQIFGKSWLQ QCTTPDGRYY RPDLNFPRSL PKRSRGIKDF ENDPPLSSCG
IFQSRMAGSK LPSEVAPLGG YSDEEGTFPT AVFQGKLCWT AASGSPQSSA PPPSAVCRRP
NIYWESSNWR KKLR
//
