ID A4GW28_MACNE Unreviewed; 273 AA.
AC A4GW28;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Programmed cell death 1 ligand 2 {ECO:0000313|Ensembl:ENSMNEP00000004823.1};
DE SubName: Full=Programmed cell death ligand 2 {ECO:0000313|EMBL:ABO33160.1};
GN Name=PDCD1LG2 {ECO:0000313|Ensembl:ENSMNEP00000004823.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|EMBL:ABO33160.1};
RN [1] {ECO:0000313|EMBL:ABO33160.1}
RP NUCLEOTIDE SEQUENCE.
RA Onlamoon N., Rogers K., Mayne A.E., Pattanapanyasat K., Mori K.,
RA Villinger F., Ansari A.A.;
RT "Studies of the expression of PD-1 on CD4+ and CD8+ T cells and its subsets
RT in SIV infected disease susceptible rhesus macaques and SIV infected
RT disease resistant sooty mangabeys.";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMNEP00000004823.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; EF444813; ABO33160.1; -; mRNA.
DR RefSeq; XP_011756873.1; XM_011758571.1.
DR SMR; A4GW28; -.
DR STRING; 9545.ENSMNEP00000004823; -.
DR Ensembl; ENSMNET00000024104.1; ENSMNEP00000004823.1; ENSMNEG00000022031.1.
DR GeneID; 105491852; -.
DR CTD; 80380; -.
DR GeneTree; ENSGT00940000161373; -.
DR OMA; ELYIVEH; -.
DR OrthoDB; 5315576at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000022031; Expressed in lymph node and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032689; P:negative regulation of type II interferon production; IEA:Ensembl.
DR CDD; cd20986; IgC1_PD-L2; 1.
DR CDD; cd20983; IgV_PD-L2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR25466:SF1; PROGRAMMED CELL DEATH 1 LIGAND 2; 1.
DR PANTHER; PTHR25466; T-LYMPHOCYTE ACTIVATION ANTIGEN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..273
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015086384"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..203
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 273 AA; 30887 MW; 8CA7A1991BA5C46C CRC64;
MIFLLLMLSL ELQLHQTAAL FTVTVPKELY IIEHGSNATL ECNFDTGSHV NLGAITASLQ
KVENDTSPHR ERATLLEEQL SLGKALFHIP QVQVRDEGQY QCIIIYGVAW DYKYLTLKVK
ASYRKINTHI LKVPETDEVE LTCQATGYPL AEVSWPNISV PANTSHSRTP EGLYQVTSVL
RLKPHPGRNF SCVFWNAQVR ELTLASIDLQ SQIEPRTHPT WLLHIFIPSC IIAFIFIATV
IALRKQLCQK LYSSKDTTKR SVTTKKREVN SAI
//
