ID A4H3I0_LEIBR Unreviewed; 717 AA.
AC A4H3I0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 22-FEB-2023, entry version 70.
DE SubName: Full=Putative glycerol-3-phosphate acyltransferase {ECO:0000313|EMBL:CAM36745.2};
DE EC=2.3.1.15 {ECO:0000313|EMBL:CAM36745.2};
GN ORFNames=LBRM_03_0090 {ECO:0000313|EMBL:CAM36745.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM36745.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM36745.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36745.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM36745.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36745.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798977; CAM36745.2; -; Genomic_DNA.
DR RefSeq; XP_001561599.2; XM_001561549.2.
DR AlphaFoldDB; A4H3I0; -.
DR STRING; 5660.A4H3I0; -.
DR GeneID; 5412519; -.
DR KEGG; lbz:LBRM_03_0090; -.
DR VEuPathDB; TriTrypDB:LbrM.03.0090; -.
DR VEuPathDB; TriTrypDB:LBRM2903_030005800; -.
DR InParanoid; A4H3I0; -.
DR Proteomes; UP000007258; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004366; F:glycerol-3-phosphate O-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102420; F:sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity; IEA:UniProtKB-EC.
DR CDD; cd07992; LPLAT_AAK14816-like; 1.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR31605; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1; 1.
DR PANTHER; PTHR31605:SF0; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:CAM36745.2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transferase {ECO:0000313|EMBL:CAM36745.2};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 532..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 183..383
FT /note="Phospholipid/glycerol acyltransferase"
FT /evidence="ECO:0000259|SMART:SM00563"
FT REGION 35..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 80102 MW; 4193D9DE8418C20C CRC64;
MAVPADRSVK FSLEEESLAH AVENEASPSV AMMPAATAAS PSMPEEFTDS TETHPTTSLP
AAASVSPTVE ETPAAACSST STAAAAVSRV APKSALKSKD RIGASLRRSK FVFCEECHQS
IPIEEWPDHR DRLRKVNLVE QVSRFHHTLV RLMGEFLMWV LRSVYFREVT VVGRENIPRA
GAVVFYGNHQ NQFIDALMMH SHCGRPVRFL MAEKSFHQPV IGTLGRMFNS VPVVRPQDVP
LVAGDGKLVR TEGKLIIGSG THFSKLSKGD VLIWGVPGNA KCRAQVSRIT SDEEVEVTVP
IPAEHEVHAP TSFKYSARID HSEMYAQVYD TLQKNHCIGI FPEGGSHDHT SLLPLKAGVA
LFSLGAVERH ISVKIVPVGL TYLYGHKFRS RAYIEFGEAF SPPDDLVKLF DTDKRKATGL
FLEQLNAALH AVTINVPDYR TLSFLHSFRQ LYQPPNCTLS GHDYLRLIRR LGNVIEEQRE
SAEFAEFREK VENYLDFCKA LMIRDSQVAT LKQLLHADSE ALQIALLLRR VFALYLMAVI
LVPFFVVGLP IGGIIKYFAL KQTKRALSES SVKIVGADVT GSFKVMFAFA VVPAAFLLVS
FIVFLYSDTR TALVILFSLP MAMYVSLLIL QEAIMELRAT LPLLMSLASQ HMQFKKLYER
REDLAKQARL IVHKYDPQLE EEMKVYVGAD DCNDDLSREP SLFSLRYNVR RRQATNS
//
