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Database: UniProt
Entry: A4H3Z2
LinkDB: A4H3Z2
Original site: A4H3Z2 
ID   PESC_LEIBR              Reviewed;         670 AA.
AC   A4H3Z2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=LbrM04_V2.0780, LbrM_04_0780;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; FR798978; CAM41555.1; -; Genomic_DNA.
DR   RefSeq; XP_001561761.1; XM_001561711.1.
DR   AlphaFoldDB; A4H3Z2; -.
DR   SMR; A4H3Z2; -.
DR   STRING; 5660.A4H3Z2; -.
DR   GeneID; 5412680; -.
DR   KEGG; lbz:LBRM_04_0780; -.
DR   VEuPathDB; TriTrypDB:LbrM.04.0780; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_040014200; -.
DR   InParanoid; A4H3Z2; -.
DR   OMA; QKVTWIV; -.
DR   Proteomes; UP000007258; Chromosome 4.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   CDD; cd17709; BRCT_pescadillo_like; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR   PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..670
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370470"
FT   DOMAIN          316..402
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          643..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          292..321
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        643..663
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   670 AA;  77267 MW;  70BF8BE9C7946BA5 CRC64;
     MAHKKQAWAK RVKKERFKKK YLTRMQATRL LQMESIQFRR LCILKGVYPR ALTRSKQKQS
     GNEKQYYLAR EIKWLVRDHI AEKMMTYRAW EKKVKRAEAM GRADDLKALQ SSRVKPRHSL
     VATIKERYPY FIDAIRDVDD AMSMIHMYAF LSPEIKSEST IEIHHSLTSG LSEKAKEMCH
     RWNRYIARAH VLTKGFISIK GYYYEAIIKG ERVRWLCPHE YAHRFPPGIQ QYVMLSFLEF
     YLEMMKFVLF KLESDLARDE ADRLAIEDEE GLTRANAEDF ASGAALAVLD VGANQAQAKV
     KEAESKRSLM EEELLKVREL FRGLTFYISR EVPAKHFALI INACGGRVAT DYVASNITHV
     VVDRPALPPG WQQHDQMEYV QPQYIFDCLN ARQMLPVTGY RIGEDLPPHV SPFSVSITNS
     AEDNAAVEQV KKDHPRIVGY VPARVHEIRK LINPSYSPVD PEGKVAQLED EYSDEEMHVA
     VPEMDMEDDV SLSGDELAEA RKKPGWQEEE VTEEVQRPKL SAFKVKKQRE MNLMNAPTNE
     VVARRRQALR KAQENLRQSE TPEARLQRKM SEVKRQEAVT RKMQLQVARK KAARFYKMVS
     GVVQGTAKKA ATLEAKAKHI AEGKLHKTED GKGLVNARLA ARRQRAEAKG KKLKEKKADN
     PYKKLPKWVQ
//
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