ID A4H486_LEIBR Unreviewed; 1208 AA.
AC A4H486;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 22-FEB-2023, entry version 88.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=LBRM_05_0410 {ECO:0000313|EMBL:CAM36875.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM36875.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM36875.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36875.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM36875.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36875.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; FR798979; CAM36875.1; -; Genomic_DNA.
DR RefSeq; XP_001561855.1; XM_001561805.1.
DR AlphaFoldDB; A4H486; -.
DR STRING; 5660.A4H486; -.
DR GeneID; 5412743; -.
DR KEGG; lbz:LBRM_05_0410; -.
DR VEuPathDB; TriTrypDB:LbrM.05.0410; -.
DR VEuPathDB; TriTrypDB:LBRM2903_050009100; -.
DR InParanoid; A4H486; -.
DR OMA; HNKIAME; -.
DR Proteomes; UP000007258; Chromosome 5.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 518..649
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1175..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..232
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 297..345
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 463..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 697..940
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1181..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 136497 MW; 9764E0EA365BA5C8 CRC64;
MRVKSIVIDG FKSYAHRKEL ADLSPHFNAI TGLNGSGKSN IFDAICFVMG ITNLKRVRAE
DPRELIFRAG TTGVHAARVT IEFVNDDPAS APPGYSCEEY PLITIGRQIK LGGRQQFFFN
NTVSLQSKVK RFFESISLNV DNPHFMILQG TVHKLIGMRS QDILSLIEEA VGTKAFDHRR
RTAETLIRNK ERKMEEIDTN IEAQIRPLLD TMRADQEEYN AFMQNREKTE EKKRFRIALD
YHTHHTEHTE VEARVEARKV DVQNAKSQLQ ALPRQEEEAT RRLVQLQGSL HAPSEAAISL
HEEEDELKKA HSRLESELDN CTRLLRQLET QLKTLRREQE KQSNNQVTFA ARRQQHEQML
AQIKEGKEAC AKLKRGLKLL QSGVQAGTSG VSLAEERQQV DLKLIEQQSR VHRATERFEE
LVKQQQRIEA HQAEESSRVR HLEHEHAKAA ASLEKTKVVY APLALKQERK EALEAEISSL
KREYQAEYEN FQRQVSTAAA RNYDLDYNRY ACPPDTEDNV LGRVGQLITP IDLQHALGLM
VGAQNQLLRV VVTDDRVAEA IIHSGLRQRT AFFALDKLQR PPTHLFIDDA KLQAARLIAE
QQGGWVHRAR DLVTVQEASS HQQQLNALAD FVFGTFFVCS SLRLAQDLAY NPSIKVKAVT
IEGEVAEPNG LMTGGSTHHL RDVFADLKAY AAQKEPLQAL QQRTRTLETE YAALRNTLRQ
HQHDIQAYKA AEAAAELSKQ RYIVAASSAQ SGAAELAEEM EREHATMTEA QEKVAVLQAR
QCELAAQAQT TDLNVVRTEI ENQLAAAEAH VARLMADEER GAAEFERLEA DMEQQTADLS
RKAQDMEEEL AQQQSQKLKL TAQVEELKQQ LVAVQARCKH NEERRQQLEK EIDDTQEELT
RLAERKVTLD NLAKNGEVEL REQSRCLESL RRHIHEAEQR HSWLLEVRET FNQPGGPYDF
SDAARTAATL QELREIEARA AAMSNKLSQK SAILYEERRR EYEELVKQRT ALGEDKEAIQ
RCITEIESKK WGALDRMVGI VSSIFGRLFA ACLPGATAQL LEERDATNHL TGLGVRVSFN
EKPRESLSEL SGGQRSLLAL CLMLAILRVR PAPLYILDEV DAALDPSHTQ NIGRMLQLYF
PHSQFLLVSL KDGMFNNANV LYHIRNTQGY SEVARIEHKP PSQPTSASSD TRAASSGADR
EGAVATSA
//
