ID A4H4V9_LEIBR Unreviewed; 616 AA.
AC A4H4V9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Eukaryotic membrane protein family {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_07_0150 {ECO:0000313|EMBL:CAM41627.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM41627.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM41627.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41627.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM41627.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41627.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TAPT1 family.
CC {ECO:0000256|ARBA:ARBA00008803}.
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DR EMBL; FR798981; CAM41627.2; -; Genomic_DNA.
DR RefSeq; XP_001562511.2; XM_001562461.2.
DR AlphaFoldDB; A4H4V9; -.
DR GeneID; 5412920; -.
DR KEGG; lbz:LBRM_07_0150; -.
DR VEuPathDB; TriTrypDB:LbrM.07.0150; -.
DR VEuPathDB; TriTrypDB:LBRM2903_070006700; -.
DR InParanoid; A4H4V9; -.
DR Proteomes; UP000007258; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008010; Tatp1.
DR PANTHER; PTHR13317:SF4; TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG; 1.
DR PANTHER; PTHR13317; UNCHARACTERIZED; 1.
DR Pfam; PF05346; DUF747; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 101..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 48..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 67503 MW; 038CF340733E84CA CRC64;
MWWEWGTVRR QTIELLLGPT AEQRHHQLQH RDQKQAYETF MTMSASAASE PRRSGGSESP
DSSPPATVGV ASAGGRHRNH EYATLRKHFQ RIPHMFLNME FYFAITALGL FDHLIGLLLL
PLKVLTLWRR CELRDIIALL VLTIVLGSYW VAGLATTQLY SYLYHAVRRT SFIKVVMIFG
ILDVVDKILS SFSQDSLEVL YTAVDDEYSY YCARRRQAKP PAASTPTKRA ASGRGYAGCD
DVGTAAASQH TPPSRWLLAG SGVVACLSTS CHSLSLLLHV VTLNVAINAE GNSLLALLVA
NNFTELKGVL FKKNTPESLH GVSSLDALER MQYIVFFFVM LLQHMHERFT DFAIADVCII
LCVEVAIDFV KHLFVFRFNG IPPSMSRAYS QLALLDLSCE TVLWRLPSLE VVVSGPSSSV
ATRMEEAAEL LTPAHGFAPK HVKRAGFDAI AYAALLLWSC ERVAGYLLLQ APLVCVLLVL
ILALLKVMLS SIVYGVCARF TLRSLVVVPP SWPPSPSQGS VPPPLNGASQ RTSVSLTSPL
VSACGVRLGV SPINTPHATP IGGSRHFQID AATFLPANSK SGPEAVRTLV QLTPLLLALL
KANRFDLHAG KAKRSH
//
