ID A4H5F0_LEIBR Unreviewed; 547 AA.
AC A4H5F0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE SubName: Full=Stress-induced protein sti1 {ECO:0000313|EMBL:CAM37176.1};
GN ORFNames=LBRM_08_0880 {ECO:0000313|EMBL:CAM37176.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37176.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37176.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37176.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37176.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37176.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FR798982; CAM37176.1; -; Genomic_DNA.
DR RefSeq; XP_001562145.1; XM_001562095.1.
DR AlphaFoldDB; A4H5F0; -.
DR SASBDB; A4H5F0; -.
DR STRING; 5660.A4H5F0; -.
DR GeneID; 5413050; -.
DR KEGG; lbz:LBRM_08_0880; -.
DR VEuPathDB; TriTrypDB:LbrM.08.0880; -.
DR VEuPathDB; TriTrypDB:LBRM2903_080016600; -.
DR InParanoid; A4H5F0; -.
DR OMA; MYSAREN; -.
DR Proteomes; UP000007258; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.260.100; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR041243; STI1/HOP_DP.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22904:SF523; STRESS-INDUCED-PHOSPHOPROTEIN 1; 1.
DR PANTHER; PTHR22904; TPR REPEAT CONTAINING PROTEIN; 1.
DR Pfam; PF17830; STI1-HOP_DP; 2.
DR Pfam; PF00515; TPR_1; 3.
DR SMART; SM00727; STI1; 2.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 3..36
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 71..104
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 131..170
FT /note="STI1"
FT /evidence="ECO:0000259|SMART:SM00727"
FT REPEAT 224..257
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 359..392
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 393..426
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 427..460
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 495..534
FT /note="STI1"
FT /evidence="ECO:0000259|SMART:SM00727"
FT REGION 189..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 62453 MW; D7DAA6F0244D5B2F CRC64;
MDANELKNEG NKEFSAGRYV EAVNYFSKAI QLDGQNSVLY SNRSACFAAM QKYKDALDDA
DKCISIKPNW AKGYVRRGAA LHGMRRYDDA IAAYEKGLSV DPSNSGCTQG VKDVQVAKSR
EARDPIARVF TPEAFRKIQE NPKLSLLMLQ PDYVKMVDTV VRDPSQARLY MEDQRFALTL
MYLSGMKIPN DDEDDEEERP SAKAAAEAKA KEEKKLLTDN EKEAMALKEE GNKLYLSKRF
EEALSKYQEA QAKDPKNTLY ILNVSAVYFE QRDYEKCITE CERGIEHGRE NHCDYTIVAK
LMTRHAFCLQ KQKKYEAAID LYKRALVEWR NPDTLKKLTE CEKEHQKAVE EAYIDPEIAR
QKKDEGNQYF KEDKFPEAVA AYTEAIKRNP AEHTSYSNRA AAYIKLGAFN DALKDAEKCI
ELKPDFVKGY ARKGHAYFWT KQYNRALQAY DEGLKVDPSN ADCKDGRLRT IMRIQEMASG
QSADGDEAAR RAMDDPEIAA IMQDSYMQLV LKEMQNDPTR IQEYMKDPGI SVKINKLISA
GIIRFGQ
//
