ID A4H610_LEIBR Unreviewed; 928 AA.
AC A4H610;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Exonuclease domain-containing protein {ECO:0000259|SMART:SM00479};
GN ORFNames=LBRM_10_0290 {ECO:0000313|EMBL:CAM37231.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37231.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37231.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37231.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37231.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37231.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798984; CAM37231.1; -; Genomic_DNA.
DR RefSeq; XP_001562800.1; XM_001562750.2.
DR AlphaFoldDB; A4H610; -.
DR STRING; 5660.A4H610; -.
DR GeneID; 5413282; -.
DR KEGG; lbz:LBRM_10_0290; -.
DR VEuPathDB; TriTrypDB:LbrM.10.0290; -.
DR VEuPathDB; TriTrypDB:LBRM2903_100007900; -.
DR VEuPathDB; TriTrypDB:LBRM2903_100008000; -.
DR InParanoid; A4H610; -.
DR OMA; HPAGLPY; -.
DR Proteomes; UP000007258; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06145; REX1_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR034922; REX1-like_exo.
DR InterPro; IPR047021; REXO1/3/4-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR12801:SF115; RNA EXONUCLEASE 5; 1.
DR PANTHER; PTHR12801; RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 486..646
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 99148 MW; 3A945DD87FC0ED3C CRC64;
MPSISLQGSH SAALDGEGPH LAHRRRPSSS APSSASSRSS SQGRPSSVHC ASSPLATPVI
VGATSSELRN GEKKSRHKKA RQGEDATREI TCPPPPAPQQ RQPHELSRGT TAPTPLQQRF
SEVELQFQLE QDRAQRSALA PHDIANLILW SVPAPVPIIE SPRVFFIKNK SHVRNAVVIY
VNGWSYDEML CTGVGLPRTR GEAHHRSAPQ EQATPPHSTA TNDSTTGHAV ESTATAANAK
DDDDSTAHWD KELCSAMLRP VREGRCWARQ SRGAGCAGGV QYCPLFIPST RNELEKDLWW
RNDALGRLRS SSAASSSAVN RFHPNFRRGG EERDGSAVHC ASPAVRDARG VGTMFQQALQ
AHAKKSGTAD GAASGDISVM AASPPAAASP TFASDAFQQY QHLWANRDLL QQYALHLPEH
TAELHELGFT LAPPPESTAA APAADEETAL QGGNGVGGAQ DSWVSFPAPS TTATADATAA
TGRGVRVVAF DCEMVQIEGG ESALARATLV DVLTGSVVLD LLVKPRQRIT DYRTRFSGID
AAMLEPVSTT LADCQQALQR LVDTQTFVVG HSLENDFKAC KCIPNCYVLD TTRLFPHPAG
LPYKNALRFL AQRYLQRRIQ QGPHNSATDA VVSAELTQLK LINGPSFGVR PRVSVLGCIT
EADPNVQIYL FDDAVTLTSL LPAPQSNASS ATYGETSGGT VPSAPPSSAA SSGRIDAVPV
RHDEDAMRKA VRALQRRVSQ QAHEAAAVAN GTDGDKAAPH RPSFSLFWVQ LTQAKVDVTL
PPAQPSAPFP AVAAGEESET GEKTPFAGVF RSCDTSSARM VAQFRRVHDT NRRVLQIIEA
CPDETIIVVL TGRCDGEAGG NHFSRAQGTC FAFVKDRSAP GPRADELTKL TDESSGSALP
RESAAAVPHH VDVKTAMIDS TPRACQQQ
//
