ID A4H6F8_LEIBR Unreviewed; 732 AA.
AC A4H6F8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Putative chromatin binding protein {ECO:0000313|EMBL:CAM41910.1};
GN ORFNames=LBRM_11_0100 {ECO:0000313|EMBL:CAM41910.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM41910.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM41910.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41910.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM41910.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM41910.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798985; CAM41910.1; -; Genomic_DNA.
DR RefSeq; XP_001562945.1; XM_001562895.1.
DR AlphaFoldDB; A4H6F8; -.
DR STRING; 5660.A4H6F8; -.
DR GeneID; 5413434; -.
DR KEGG; lbz:LBRM_11_0100; -.
DR VEuPathDB; TriTrypDB:LbrM.11.0100; -.
DR VEuPathDB; TriTrypDB:LBRM2903_110005900; -.
DR InParanoid; A4H6F8; -.
DR OMA; RLTHISC; -.
DR Proteomes; UP000007258; Chromosome 11.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF58; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF13540; RCC1_2; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT REPEAT 39..126
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
SQ SEQUENCE 732 AA; 77739 MW; E0D18D7F430C47DB CRC64;
MSEIALIDDF LPTFAFAATV GEVLQVACGA YHTLVLTTTG LYGWGLHEDG QLGLGRPSTP
SALAAAEGSA LGDVGATAVT VPTHVDQPLR IPFAELLGGD EAVEDVPVTI ISVHCGADHS
FVCSTAGVYV TGRNDCGQLG LGHTDNVYTW TRLCVALPPR TADENANHTA ATSRAASPMM
SSLPSAWDAD RGGRHAWLLY GRLTHISCGA HHTLLAWCDA VILRAAAPPS PDSQQPPVKC
SRSHELVYYP SLLMACGRGD FGELGYDGDT WAVLQAKAQR QERALRSALQ QKQAHDGIDD
SQHGATDGTY KLKWKAAAAV KQRRPPFNST FFEVVEGVDV LEESAVTLPM TCTEDMPSAL
LHRGWTIHEL AEDVIRKCHE RTATDCLRLP PTTSALQTSS GGQSRWEVAK LQAMQHHSAV
TLRQRHEEGE EQQLVLHWGC YYCSDIEDAA ASHPRDVFAD VRDAVNRDYA GVATAGLRCW
YGGIHAGEES LLRYSSSCRP SVPEMPPALA REENVASSPC GIPPSQVPLL QIMGSGNLGL
GTDDSFTCDW TSLAWSDGPM TAGGQATVHS VVGRSHYLIW THGQGVSSPV GDPSAAAAPL
RERLPAASSS CVFGFGDNLH GQLGAPALQA SNTSGDDVVV APRPVLRDGN VLRVAAAVKQ
SLRDTAVPPA RHHRSAAAKT SEPFTAAVGV HYEVVAIRAV EAGARHSVFL VDVRPVTSAA
ASVSATPATT RD
//
