ID A4H761_LEIBR Unreviewed; 345 AA.
AC A4H761;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 03-MAY-2023, entry version 81.
DE SubName: Full=Oxidoreductase-like protein {ECO:0000313|EMBL:CAM45617.1};
GN ORFNames=LBRM_13_0540 {ECO:0000313|EMBL:CAM45617.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM45617.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM45617.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45617.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM45617.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45617.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798987; CAM45617.1; -; Genomic_DNA.
DR RefSeq; XP_001563197.1; XM_001563147.1.
DR AlphaFoldDB; A4H761; -.
DR STRING; 5660.A4H761; -.
DR GeneID; 5413691; -.
DR KEGG; lbz:LBRM_13_0540; -.
DR VEuPathDB; TriTrypDB:LbrM.13.0540; -.
DR VEuPathDB; TriTrypDB:LBRM2903_130011100; -.
DR InParanoid; A4H761; -.
DR OMA; VDMSYSR; -.
DR Proteomes; UP000007258; Chromosome 13.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08250; Mgc45594_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43677:SF3; PROSTAGLANDIN REDUCTASE 3; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 21..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 345 AA; 37301 MW; F3FD2FEBFEE6B8B0 CRC64;
MQAMATAART YRHIVARELS TDFRAITSIV EAPFPTELHP KAILVKNKYL GINASDINFT
AGIYQPEVRP PFACGFEAVG EVVDVGSGVK DLKAGVAVVT QSYGAFAEYQ VVARRHAKPI
PCLAREYLPL DLSATTASIA LEHVLKPQPG ERAVVTAAAG GTGQFAVQLL KHVYGCSVVG
TCSSPSKEVF LTDTLKCDAV VNYRAEGNNT AAAFMQCYPR GITIAYESVG GDLLEAVIQS
LTLRGRIVSL GCVSTYQNGS VEAVRPSHKP LPLQLLAKSA SLSTFFLPHF AKYGQQHFDR
LCALHERGVV QSCIDPTTFK GLEGVYDAID WMWEQKNCGK VMVEL
//
