ID A4H7R8_LEIBR Unreviewed; 403 AA.
AC A4H7R8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Tub family protein-like protein {ECO:0000313|EMBL:CAM37585.1};
GN ORFNames=LBRM_14_1150 {ECO:0000313|EMBL:CAM37585.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37585.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37585.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37585.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37585.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37585.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129}.
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DR EMBL; FR798988; CAM37585.1; -; Genomic_DNA.
DR RefSeq; XP_001563401.1; XM_001563351.1.
DR AlphaFoldDB; A4H7R8; -.
DR STRING; 5660.A4H7R8; -.
DR GeneID; 5413912; -.
DR KEGG; lbz:LBRM_14_1150; -.
DR VEuPathDB; TriTrypDB:LbrM.14.1150; -.
DR VEuPathDB; TriTrypDB:LBRM2903_140017500; -.
DR InParanoid; A4H7R8; -.
DR OMA; RERIYYR; -.
DR Proteomes; UP000007258; Chromosome 14.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR PANTHER; PTHR16517:SF7; PROTEIN KING TUBBY; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR PRINTS; PR01573; SUPERTUBBY.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 306..394
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 267..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 43122 MW; 64D1BCF4711F1CE6 CRC64;
MNAVIPARLT EDVVRCAFGS DTAPSLASGA VAGESGACPG SGRACSIIMP TCKEGSDAAS
MYSMSQSVLP MDPRERIYYR PRRHLLQCYL ERRKLKGLGI TSLLPGTRKS FQFFLECTND
FVLAAVPRSL RSRIKVEDTS SGASGQLYPV TQGGANIVFT INQQQLDGDT RSFVGKLSRR
GNGMEMVMFS EGSKATRKEI LAVLLHNFAD TSQSSLTVLL PAIDPASGYI KPLEGGEVKF
LRDGRGSLGG ATENSDDDVD PAYLTTSSAA PSSVPVGDSS RANSASALNS GETCGRQKKR
CSHGVLASEY RRSPCSPSIV VLNSKTPEWD GVLRGHKLDF HGRATKASEK NFQLVAASDP
GKVVMLFGKQ SDDRFALDFR YPLCGLQAAA IATTVMTARK AII
//
