ID A4H993_LEIBR Unreviewed; 865 AA.
AC A4H993;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE RecName: Full=Protein SDA1 {ECO:0000256|RuleBase:RU365057};
GN ORFNames=LBRM_17_1500 {ECO:0000313|EMBL:CAM37963.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37963.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37963.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37963.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37963.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37963.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- FUNCTION: Required for 60S pre-ribosomal subunits export to the
CC cytoplasm. {ECO:0000256|RuleBase:RU365057}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU365057}.
CC -!- SIMILARITY: Belongs to the SDA1 family. {ECO:0000256|ARBA:ARBA00005783,
CC ECO:0000256|RuleBase:RU365057}.
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DR EMBL; FR798991; CAM37963.1; -; Genomic_DNA.
DR RefSeq; XP_001563916.1; XM_001563866.1.
DR AlphaFoldDB; A4H993; -.
DR STRING; 5660.A4H993; -.
DR GeneID; 5414448; -.
DR KEGG; lbz:LBRM_17_1500; -.
DR VEuPathDB; TriTrypDB:LbrM.17.1500; -.
DR VEuPathDB; TriTrypDB:LBRM2903_170022000; -.
DR InParanoid; A4H993; -.
DR OMA; AMYKTYK; -.
DR Proteomes; UP000007258; Chromosome 17.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027312; Sda1.
DR InterPro; IPR007949; SDA1_MD.
DR InterPro; IPR012977; SDA1_N.
DR PANTHER; PTHR12730; HSDA/SDA1-RELATED; 1.
DR PANTHER; PTHR12730:SF0; PROTEIN SDA1 HOMOLOG; 1.
DR Pfam; PF05285; SDA1_dom; 1.
DR Pfam; PF08158; SDA1_HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365057};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365057};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|RuleBase:RU365057};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365057}.
FT DOMAIN 58..433
FT /note="SDA1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08158"
FT DOMAIN 613..791
FT /note="SDA1 middle"
FT /evidence="ECO:0000259|Pfam:PF05285"
FT REGION 494..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..639
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..662
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 96968 MW; 7F62B2ACD2023DC4 CRC64;
MTEPAFRGTL LLLQNRTRRD PESYRDEFLA QLDHFRASSA TVLSQHSLNP QFTAVLNYVC
HVSHCFPKDA GVIVNIVMEL LRASKGNGVP KDLRLALVKS LILLRAKGLV STDQTFPLFF
KLLQERDKTL RKMILTHVVS DIRKVNLPGA KNGAQTNRKA QSFLFSVMAE DDPVQARCAE
MVMIDLYRRR VWSDERTVEV LTKACFSKHT PILRTALRFF LLQMPRITSM NDEGGEDAEE
QDPGRTISKL KQKVKIVKKT SKRERVLKRS VRGVKRKYDR QEREEELFAK QHVDPIRLLR
DPQQFVERLL AKLQKTSERF EVRLLYLNVI ARVVSEHEVL HLPLYGFLER YMEPSQLHAT
QLLALSAMCV HKMVPPDAIE PLLRTIANHF VSDRSSADAI TVGINTIREI CKRQPLAMNA
DLLKDLAEYK SQRGDKGVMM AARALIQLYR DVYPELLPAK LRGGKAGAVD VTKKPVYGST
HVYTDIPGLE LLYHDIDNDD GSDRGDSESS SSEDDSTSGE WATDSDSEAN GDDVDGKFVD
VPNSSAEEED EGEDVCPQLV PVYEHNHSGA DRTDAVDEGP HKRTRLEDAA PAAVASQNGA
TLSQSATDGE DEETGSDGDD YEAVSDDESD TEEVSSESDD GDSAFGWESS SDDEESAEAE
NEEEPTSLSV ALANASSDTE WFEDLTGDMG TNASLSHRPA SVSSSKASST TSMASSRLLT
DSDFQKINQL RAQHGSHLSL RGKLKERDAR TKKRHELIHG ISNDLDAHDV ELFTEKKREA
DKQGMIEQAQ ELRKASSKFE LQRKKKTKLN STHGEHSKRG KLFQMTKRSQ RVAAKLKSSV
ADRATRAKEM QKKDIKFRIK RGWKA
//
