ID A4H998_LEIBR Unreviewed; 483 AA.
AC A4H998;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 13-SEP-2023, entry version 77.
DE SubName: Full=Putative zinc-finger protein ZPR1 {ECO:0000313|EMBL:CAM37968.1};
GN ORFNames=LBRM_17_1550 {ECO:0000313|EMBL:CAM37968.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37968.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37968.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37968.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37968.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37968.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the ZPR1 family.
CC {ECO:0000256|ARBA:ARBA00008354}.
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DR EMBL; FR798991; CAM37968.1; -; Genomic_DNA.
DR RefSeq; XP_001563921.1; XM_001563871.1.
DR AlphaFoldDB; A4H998; -.
DR STRING; 5660.A4H998; -.
DR GeneID; 5414453; -.
DR KEGG; lbz:LBRM_17_1550; -.
DR VEuPathDB; TriTrypDB:LbrM.17.1550; -.
DR VEuPathDB; TriTrypDB:LBRM2903_170022800; -.
DR InParanoid; A4H998; -.
DR OMA; PVQSQKG; -.
DR Proteomes; UP000007258; Chromosome 17.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.60.120.1040; ZPR1, A/B domain; 2.
DR Gene3D; 2.20.25.420; ZPR1, zinc finger domain; 2.
DR InterPro; IPR004457; Znf_ZPR1.
DR InterPro; IPR040141; ZPR1.
DR InterPro; IPR042451; ZPR1_A/B_dom.
DR InterPro; IPR042452; ZPR1_Znf1/2.
DR NCBIfam; TIGR00310; ZPR1_znf; 2.
DR PANTHER; PTHR10876; ZINC FINGER PROTEIN ZPR1; 1.
DR PANTHER; PTHR10876:SF0; ZINC FINGER PROTEIN ZPR1; 1.
DR Pfam; PF03367; zf-ZPR1; 2.
DR SMART; SM00709; Zpr1; 2.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000313|EMBL:CAM37968.1}.
FT DOMAIN 49..207
FT /note="Zinc finger ZPR1-type"
FT /evidence="ECO:0000259|SMART:SM00709"
FT DOMAIN 266..427
FT /note="Zinc finger ZPR1-type"
FT /evidence="ECO:0000259|SMART:SM00709"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54343 MW; E6B1ED4811AD6121 CRC64;
MSERDHDEKS VTAEGPAAAQ EGSDNDSNGE GEHANYIKTD LGEMNVIESM CPKCQETGTT
RLMITKIPHF KEIIVSSFNC PHCDESNNEV TFGGTFGPKK VRYELQVKSK KDLDRQVVKS
EFATVTVPEL ELEIPPESQK GSLTTVEGIL EQTYYGLQLQ QPLRKIQHPE VCEKIEAFCV
KLESLRSGDV PFTLTLDDPA GNSYIEPLHD YYHPTLDQQL TKYETERTDI DRQLLGIPID
YNTERTQEEE RDVAEGQFSD VTQIPCDCPA CRKAGYLMMH ECDIPYFKQT IIMAFKCDYC
GYKSNEIKTG GEINAKGLRL TLHVKSEDDL KRDVLKSETA TLIIPEVHLE LSPGTLGGFF
SSVEGTISQV RDQLNSLPQA AFAVGDSADD NSKTLLQFVK ELDELLALKM EFTFILDDPL
GNVYIQNPRA HLPPPDDADP KLESEEYIRT EEQDEELGIS AMCRNEQHAD VAEVEDPEQE
NRE
//
