ID A4HAN8_LEIBR Unreviewed; 1944 AA.
AC A4HAN8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=ATP-dependent RNA helicase-like protein {ECO:0000313|EMBL:CAM38470.1};
GN ORFNames=LBRM_20_1240 {ECO:0000313|EMBL:CAM38470.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM38470.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM38470.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38470.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
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DR EMBL; FR798994; CAM38470.1; -; Genomic_DNA.
DR RefSeq; XP_001564408.1; XM_001564358.2.
DR STRING; 5660.A4HAN8; -.
DR GeneID; 5414955; -.
DR KEGG; lbz:LBRM_20_1240; -.
DR VEuPathDB; TriTrypDB:LbrM.20.1240; -.
DR VEuPathDB; TriTrypDB:LBRM2903_200021300; -.
DR InParanoid; A4HAN8; -.
DR OMA; CFMHAEQ; -.
DR Proteomes; UP000007258; Chromosome 20.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd00048; DSRM_SF; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF235; DEAH-BOX RNA HELICASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:CAM38470.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 910..1075
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 177..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1902..1944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1907..1936
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1944 AA; 211797 MW; CB06713024DAD678 CRC64;
MTIRCLAFAV ASPRLPSTHH HTRQQNDAES VRALLHIRFS SSVCVCVHSH GAIGGARSTG
SSSTPLSEMP HACWQNSVFP LLSRHRLLGY PLFFAPSPLP HPISFSLADM GTFSHFFIRG
SGLCVIATVP GMCSSMSCPC WRPWRMQTRQ WEGRSCVLLT VATVACHLSN GRAGTAHVPG
NSGAFSHTSS SAPRYRSQEC GAIDSRASPQ PHRVVRCCLK RTTPSPAKEA VSPAVKSSSR
DESSLAALLI SLETVGPSNT QRQQSALPTS SRKRTPRLTP TLFSPAKSQA RAEPKPTPVL
SPSSSCFPNN STAASELKRT GNPTQRPPHK CAEMNRYSDK PLQEGTFSSM GEQREQRVQL
RRARRRMSRT PQASRIRSLP GGRLEDATGV SPLAVDRGAE KRVVEMLRRS QQQTSPDAEF
AMRDPTVHHI PHSKLMRCVL ELPLSSRCDG DGAEQKEVFA IGQSRKAKIA RALCFMHAEQ
LLDHYMSSRG RPSSPTAGAS AVPPPLEEAV LPPLPKTPQP HEYRSWDEYV DASAAYVQAV
AAHVKQEGYM REEVLQSGHP VVDRATELLR RYPKRYCRPT ALQDLNESLR DASSLMTTAH
LAGTVFVATL VLDSRTGLTA TGVAKNMKTA KRQCAAHALC ILQLLKEDVE RQQEADGTGH
SRRRGAQKGS SGSSTKKGLS HQPSAPLESI LRQLQPAYRR IVQYHHLLFG KASLTPQTSF
TKESNTTSGS NSTITYRCHL TLNGLCCDAT GINRFEAERA AMEAAMTNLM LYDERLQAVQ
AFVNAHLSIS PESIPSAALP AELVFQLQAQ LRQVTQQPED VAADAATDVA TGKTGSDDGA
DIADDRSDRA RGMSERALLD LTQRSFARDP SYAAQMLQSM LALRRNPVYL TQFHPCRSTL
AMATVKAQLL DAVQRHRVTV VCGTTGCGKT TQVPQYILDY EIEHGRGGLC NILVTQPRRL
SSFSIAERIA QERLGTVGED VGYAVRLDAR PGRHITICTT GVLLQIFSTH PELEHISHLI
IDEVHERDIN CDVVLALVKQ LLARNLRLRV VLMSATMQAD VFARYFGTDT PVVQVEGAVY
PVTIRYLEDI AAEAATAQFC SPSLDAVSSA DSDQQDEGKK REHTTPIPLV KSSTTASRRV
NTRKYLKIDY NLIAYLVHRS VQVDLQNNTD GKSILVFLPG WKELTSAMAA IMEYSGPYAL
PDAKGRFYII LLHSTVDNAK QRECFMPAPP GTVKVVLATN IAESGITIDD AAVVIDTGLI
KTTSWESRPT LPCHQGTTDT IGSSTSRRPT VAHVPLEKVP EDGRAGGSRG SGDTAASTPF
FSTQLTLGYA SQANCTQRKG RAGRTQGGMC YRLFTKELWN SLPAFPEADI HRVPLMQVLL
KLLSLGHANP KATLQTFLEP PSSTNVDASM EVLRGISAVG KTDALTPLGE YLALLPCDPR
IGKMIIVGAV LRCLDSVLTV AACTDVCPYV TSRDVAAEAR KRRYLLSRSS QSDHISFLNA
YNAFCANGEK EDFARLNLLH LGNLRVISKY KAQYRDILRH AGLISAQDEL EEDGEMVDSI
DAAGDPVHGH LGGDSGTIKE TAVHSEGGKL NLSSGDSRTQ DVRVPGWVPL SYPGTLCVDT
SALSRHSFDV ALVKACVCAA LFPNVALLRP PANTLSSMRR LHAARKVELR TKHFFSIKPT
KDSVCRRVDG PRGGDAPGRD ELLRELRRDS QAVTTDSTTS STSPVQPVPA LFYVFQDVFG
VRDPRRDFLT SLSAVSLWAL LLFGASESTT EYNAELSICV VDGWIAVHID RATYALVTQL
RQSLFQCLRR KYHNPQDPQN NSALKTVTEV CRRLLKAPVL EMPAAKSLDT AGSTTCKTAA
GRQQSPWQLV DMGTIIDPLV HLRHGDSADG SATAVAGENA LLNLDGGGDG DEDDDNEGLP
NFNSVDGDDD DNDGNATEDG DQLK
//
