ID A4HBV5_LEIBR Unreviewed; 403 AA.
AC A4HBV5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Programmed cell death protein 2 C-terminal domain-containing protein {ECO:0000259|Pfam:PF04194};
GN ORFNames=LBRM_21_1180 {ECO:0000313|EMBL:CAM38898.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM38898.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM38898.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38898.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM38898.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38898.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798996; CAM38898.2; -; Genomic_DNA.
DR RefSeq; XP_001564823.2; XM_001564773.2.
DR AlphaFoldDB; A4HBV5; -.
DR STRING; 5660.A4HBV5; -.
DR GeneID; 5415383; -.
DR KEGG; lbz:LBRM_21_1180; -.
DR VEuPathDB; TriTrypDB:LbrM.21.1180; -.
DR VEuPathDB; TriTrypDB:LBRM2903_210016400; -.
DR InParanoid; A4HBV5; -.
DR Proteomes; UP000007258; Chromosome 21.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR InterPro; IPR007320; PDCD2_C.
DR PANTHER; PTHR46421:SF2; PROGRAMMED CELL DEATH PROTEIN 2 C-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46421; PROGRAMMED CELL DEATH PROTEIN 2-LIKE; 1.
DR Pfam; PF04194; PDCD2_C; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 185..353
FT /note="Programmed cell death protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04194"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 43899 MW; FFD28E8C49F0FDE3 CRC64;
MSHKRDQLTS ETKIGGTPTY FPPFSDADKT QIRRWTSCGV CGHAMSMLVQ AYSPLPTAPA
THPHHRMVYV FACNSGYCAS QPTSSMVAFS VQVDQEDEQA LSENAGEEED EVIETGPLLP
SELPEAVLPP CYVYIDAEPS KEVVVPTDIE RELIKMAEKN TRSTVTDEEL QQLEQTMDLK
DKKMDYYYEK FRSRVARAPN QVLRYYQRTV AAAEATSALS RAKDVRPIFM NPDKVKAMVT
IPACACCGSA QTAELQVMPT ALYYLHVSEY TALARAGAAV KQVPLSSTSA STTVDTVRGA
SASSGATTGT EQTMTANVDD GCDFGTITVY VCGKDCAARQ HGVVLRRETL CVEEAPTMRD
EERAEKADAA QAGTDGATRK VTLRELLHGK EESDDGDEAV TTA
//
