ID A4HCM0_LEIBR Unreviewed; 332 AA.
AC A4HCM0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 22-FEB-2023, entry version 76.
DE SubName: Full=Agmatinase-like protein {ECO:0000313|EMBL:CAM36515.1};
DE EC=3.5.3.11 {ECO:0000313|EMBL:CAM36515.1};
GN ORFNames=LBRM_23_0080 {ECO:0000313|EMBL:CAM36515.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM36515.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM36515.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36515.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM36515.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36515.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742}.
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DR EMBL; FR798998; CAM36515.1; -; Genomic_DNA.
DR RefSeq; XP_001565081.1; XM_001565031.1.
DR AlphaFoldDB; A4HCM0; -.
DR SMR; A4HCM0; -.
DR STRING; 5660.A4HCM0; -.
DR GeneID; 5415654; -.
DR KEGG; lbz:LBRM_23_0080; -.
DR VEuPathDB; TriTrypDB:LbrM.23.0080; -.
DR VEuPathDB; TriTrypDB:LBRM2903_230005600; -.
DR InParanoid; A4HCM0; -.
DR OMA; IQAIYAK; -.
DR Proteomes; UP000007258; Chromosome 23.
DR GO; GO:0008783; F:agmatinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR11358:SF42; ARGINASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11358; ARGINASE/AGMATINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CAM36515.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
SQ SEQUENCE 332 AA; 36560 MW; 383B2139829C7925 CRC64;
MFTKFLSRVR ALPPRSGDWA NKLGPVALMG YSGGAHMSST KLLNHFYESP RDCDMYAELT
FHEPGPVECP PETVIFLPVI QCGEMLNDTN EPSGVTEDDW YVALTEATTE LLEKGYVPVS
AGGDGSATLA MIEAYKRLFQ SSEVVLIHFS SKPSLERAEQ PIRVLLEKDL LKGVVEIGNR
CVSSGDRKIR KQNKIMYMDI QAIYAKGLFC IRDIRNDYPV FLSIDADVLD PAFAPAVQSP
VSGGLSIRDL LHIMAGIRGP KVAGIDIHGY HPTLDVCRGD GLGLTQMALA KVLKESIVKA
YTISTQTAEE GLERVRMLQR QGTLSDNPYP DH
//
