ID A4HDN4_LEIBR Unreviewed; 397 AA.
AC A4HDN4;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Aminomethyltransferase folate-binding domain-containing protein {ECO:0000259|Pfam:PF01571};
GN ORFNames=LBRM_24_1800 {ECO:0000313|EMBL:CAM42355.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42355.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42355.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42355.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42355.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42355.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR798999; CAM42355.1; -; Genomic_DNA.
DR RefSeq; XP_001565444.1; XM_001565394.1.
DR AlphaFoldDB; A4HDN4; -.
DR STRING; 5660.A4HDN4; -.
DR GeneID; 5416024; -.
DR KEGG; lbz:LBRM_24_1800; -.
DR VEuPathDB; TriTrypDB:LbrM.24.1800; -.
DR VEuPathDB; TriTrypDB:LBRM2903_240025700; -.
DR InParanoid; A4HDN4; -.
DR OMA; WEADPRT; -.
DR Proteomes; UP000007258; Chromosome 24.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.160; -; 1.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR InterPro; IPR045179; YgfZ/GcvT.
DR InterPro; IPR017703; YgfZ/GcvT_CS.
DR NCBIfam; TIGR03317; ygfZ_signature; 1.
DR PANTHER; PTHR22602:SF0; TRANSFERASE CAF17, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR22602; UNCHARACTERIZED; 1.
DR Pfam; PF01571; GCV_T; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 17..113
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT REGION 120..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 43264 MW; 64E81C1ABFE58024 CRC64;
MKPLAPFVCR LPSRRILRVR GTDAHEFLQG IFTNDLHELH PNGSMYGCFL YFTGRVLCDA
HLYQCKQLHE RQASILVDVH ESSVAELLDH LTEMKMRKKV HIDDVGKELV VLAALEETSA
APPTGADAQR SSNFGSSSDA RVSSVTSSSP KTLEERHTEC FADPRNNALF PQSPPPYCKP
ASDSEDAAAT FVTGPPPTSS LPPATDSVAT PLNWFLRRCV VPATWAPPLS SVDPYTTLLY
SRGIGEGPGV FKNKSLPFEG NLDFLKGVSF HKGCYLGQEL THRTHVMLVT RKRTVPLHFG
PTSGGPPAVS TTTDDGAVAT TRPVEIGEPL YSAAKEKIGV VTGVCGQVGV GLLRLRYVDK
ATHTVPGLQL KDGTPAQTHL PDWWPLKEVR RLLKNNA
//
