ID A4HEC5_LEIBR Unreviewed; 439 AA.
AC A4HEC5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=COP9 signalosome complex subunit 2 {ECO:0000256|ARBA:ARBA00014879};
GN ORFNames=LBRM_25_1790 {ECO:0000313|EMBL:CAM39178.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39178.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39178.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39178.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39178.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39178.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN2 family.
CC {ECO:0000256|ARBA:ARBA00009318}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR799000; CAM39178.1; -; Genomic_DNA.
DR RefSeq; XP_001565683.1; XM_001565633.1.
DR AlphaFoldDB; A4HEC5; -.
DR STRING; 5660.A4HEC5; -.
DR GeneID; 5416268; -.
DR KEGG; lbz:LBRM_25_1790; -.
DR VEuPathDB; TriTrypDB:LbrM.25.1790; -.
DR VEuPathDB; TriTrypDB:LBRM2903_250031200; -.
DR InParanoid; A4HEC5; -.
DR OMA; SEENWKD; -.
DR Proteomes; UP000007258; Chromosome 25.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.570; -; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10678; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR10678:SF3; COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR Pfam; PF01399; PCI; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 251..415
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 439 AA; 49659 MW; 83628745012D4AF1 CRC64;
MEDDYYYDDD GGYDEYYDNG ADEVVDVDPL EVKYVDGKSF MQSNVGESLR CLQEVMAEDN
EHGKWTFKAL RMLARASRIA KKYDAMTDYY TRVVHFTHPD IGAAAVAKAM LKFTEESQQV
PAEWRGRTLH VTLEVATAQP ESYRDVIVPT LLRRATLFVE EAKYEEALLD LQAALQKCDE
SGVTTAQVNT NSVYHIRSLQ LTVYRKLSRY AELRRAYYEL DRVQAALPSL RMIGSVMESA
GHLFLHDADW AAAHRAFSLA LRCHTESGCA QQYSVIKYIV LAAIMDGTPT DVFAQEETLA
NHSSVRPVRA LWQAFIALDI STFLHVLRAP ANAVCFTKDE EFAPYVEPMM FQLRTNYLIS
YSKSFGTLSL LELGARLQLQ EQPCKELCTS AILLGLIDAR IDDSRKLLLF QRASRTVPSS
VAVLRDLSGM TSELCCMYR
//
