ID   A4HEF7_LEIBR            Unreviewed;      1470 AA.
AC   A4HEF7;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Raptor N-terminal CASPase-like domain-containing protein {ECO:0000259|SMART:SM01302};
GN   ORFNames=LbrM_25_2140 {ECO:0000313|EMBL:CAM39213.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39213.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM39213.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39213.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAM39213.1}.
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DR   EMBL; CADA01000032; CAM39213.1; -; Genomic_DNA.
DR   STRING; 5660.A4HEF7; -.
DR   VEuPathDB; TriTrypDB:LbrM.25.2140; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_250013100; -.
DR   InParanoid; A4HEF7; -.
DR   OMA; ELRSWAC; -.
DR   Proteomes; UP000007258; Unassembled WGS sequence.
DR   GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR004083; Raptor.
DR   InterPro; IPR029347; Raptor_N.
DR   PANTHER; PTHR12848:SF19; RAPTOR N-TERMINAL CASPASE-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR   Pfam; PF14538; Raptor_N; 1.
DR   PRINTS; PR01547; YEAST176DUF.
DR   SMART; SM01302; Raptor_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          114..281
FT                   /note="Raptor N-terminal CASPase-like"
FT                   /evidence="ECO:0000259|SMART:SM01302"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          604..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1470 AA;  161034 MW;  CD2B584B08C6501B CRC64;
     MLNRRRNTDQ RRGPSSAVAP SPGSGGATAV PAAIPGSASD GTSSALVTVA AGSSSHAHEL
     HSSRALDEVI SERVAAFAPS NLPSLVNDDT MDEASGGLDT LGDVTLVRAT TRYRVRITHA
     VLLMYLHIGN DPPGFPRVEP CAKMECWVDP MVAHVATSAY RGSRGTGAVG GSDSIAEALE
     RQYRTVLRDE VCVMRVVEAS LEVSKLALVN SRRMARDGRI LVHYNGHGMP RATDLGEVWV
     FDKERTHYVP LNITEIAELV EAPAIYVFDC NSAGSLLQRW CRDQLQEKRP HDLLICACGP
     GETLPLSPAL PADLLTSCLT TPLRMALEWY IGFSFHAVLL PHVTADMIRN IPGDYNDRKS
     PRGELNWILN AVTDTIAWCT LPPAQFHYLF RQSTAVKGIF RNCILADRLL RESGCTPMTY
     PALSQEAHLH PMWELWEYVV DKCVSQLPRL FAATDGVPTA YEPSTFFDDQ LTAFEVWVES
     GDMAEVPEQL PCVLLALTQV QYRVRAFTLL AKYLDSGRTA GKRAILCGIL PYMSKLVTQA
     PEVFLIVAVL WMQVVRADPV EGCNEMQKCQ CEKYLISLLK LEEASTSIEY VEYGQMVNYV
     RGESPQLPSP SFSPTSTTAA PRQKRPDSQP RLQAWASTAS LDGAAEQPLQ PMQPMSSLLA
     EAPPRSAPPG QVAAKLNSVA SHLVHPGHTV YFLMKDVNLS RCKSMSCYVL CQFLQRGERQ
     CILSWNNRLL NAAFPCLSST NAELRSWACL VLSRLFLGLR HAKKFASKEC ASRLDLFTRL
     LQDRSPVVRS SCVTLLASIV GVRVDFLPHE QQVRRLHMEK SLLIKLREYV FDASMNVREE
     LIFFCCEVLH AYRSVLSPAH REKISEYVLE VGQQGSQWAL EEAEVGVKSQ LNVARPTVNA
     LFDDTVVFET SFLTADDPLP PTRELEASKL SPAALQIVEG LLHDAALVLC MLYANCDSVL
     VNKALRCLAT GVPPQSQRFA SEALRTMSRV TSAESAEYWS EADRTRATWN TDIMRQLVLD
     MRDRKLEPHR RYTSAGSSPL FSQNPNWHVT TSGNGAASAA SLLASRKNTE AERHLVLRSA
     VRPDAVACTA FRALEASMVV ATKDQRIWYV SYDNYDSQQE LHSFAVQLSG PLHDVHIIND
     LSEQSGLLLV DKRGGFTLMK GCWDPNSVPT GAAVFSACPP PPANRWLDLK STYRSSAAVL
     FYGGPIATDG GTAIHMMSLA EEQVVQRLSV SGNPVLTSLE THTTQRALLA GFSDGVVRYY
     DDRQRQGQMG AVGMVSCRAP AMALTAPMEA VVGAGPVATN TGFAIAAATR SCFFIFDSRK
     LSEPQLCVTN QDLYYGRGGL ERALLDNGSI DTDAAATSLS LSLPTTSTIH APGPPPAPRI
     MRCSVGIHTG LVGLCFQNNT YAAFNTKGLI LNEYPLTVMM GGAGESTLSQ QHQQQQGQHA
     SCLPILPGSC VAHPLRPLMS FGGELMFLQL
//