ID A4HEN1_LEIBR Unreviewed; 314 AA.
AC A4HEN1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Serine aminopeptidase S33 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_26_0250 {ECO:0000313|EMBL:CAM39287.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39287.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39287.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39287.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39287.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39287.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. LDAH family.
CC {ECO:0000256|ARBA:ARBA00008300}.
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DR EMBL; FR799001; CAM39287.1; -; Genomic_DNA.
DR RefSeq; XP_001562259.1; XM_001562209.1.
DR AlphaFoldDB; A4HEN1; -.
DR ESTHER; leibr-a4hen1; LIDHydrolase.
DR GeneID; 5416377; -.
DR KEGG; lbz:LBRM_26_0250; -.
DR VEuPathDB; TriTrypDB:LbrM.26.0250; -.
DR VEuPathDB; TriTrypDB:LBRM2903_260007300; -.
DR InParanoid; A4HEN1; -.
DR OMA; WVPVSYY; -.
DR Proteomes; UP000007258; Chromosome 26.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0019915; P:lipid storage; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR019363; LDAH.
DR PANTHER; PTHR13390; LIPASE; 1.
DR PANTHER; PTHR13390:SF0; LIPID DROPLET-ASSOCIATED HYDROLASE; 1.
DR Pfam; PF10230; LIDHydrolase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
SQ SEQUENCE 314 AA; 35037 MW; 54F634DAC1D5E242 CRC64;
MSSPNTIVAW KAPVAGGVVV DVLQSSSNLL QYLTTVESSN GGCELPNSNR KLLVFFPGNP
GLVQFYEPMC ACLEKNKFDV LVMGYAGHSL TQLNKGRVFS LAEQMDIADS FVATLINKNT
ELKYKKNIYV GGHSIGGFVA LQMGARYASI KKCFGLCPVI SHLRDSPNGR RLFYLSNTVT
QCCVAMGAAL LELLPYKLRH LLIARWEPKL SPALAEALAH HCHRWCLMNS LYMAMTEFRM
LLQPDAVLLR HVQERLILYY VQNDGWAPLS YAEEIKRICP QLGAYVLEED AGVPHAWCLD
RSETVVRNAI LKHC
//
