ID A4HEY4_LEIBR Unreviewed; 590 AA.
AC A4HEY4;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 03-MAY-2023, entry version 62.
DE RecName: Full=JmjC domain-containing protein {ECO:0000259|PROSITE:PS51184};
GN ORFNames=LBRM_26_1310 {ECO:0000313|EMBL:CAM39393.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39393.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39393.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39393.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39393.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39393.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799001; CAM39393.1; -; Genomic_DNA.
DR RefSeq; XP_001562362.1; XM_001562312.1.
DR AlphaFoldDB; A4HEY4; -.
DR STRING; 5660.A4HEY4; -.
DR GeneID; 5416483; -.
DR KEGG; lbz:LBRM_26_1310; -.
DR VEuPathDB; TriTrypDB:LbrM.26.1310; -.
DR VEuPathDB; TriTrypDB:LBRM2903_260018200; -.
DR InParanoid; A4HEY4; -.
DR OMA; VEAANVW; -.
DR Proteomes; UP000007258; Chromosome 26.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR12461:SF97; BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7-RELATED; 1.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 313..586
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 70..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65018 MW; 80ECE4BB41B29734 CRC64;
MSASAVSSTT SDRPPLTLLE AFANSAAALR HFGIPRIRVV GLSEGCAQED YELQRARPGA
KDLESLLQES SLCGPHGGRE TASRRVQSEQ GSPSEAVASQ DVPIVTEQEF MHMFVFHSRP
CVILDALAAW PALHKWRDDR YVFDLDHTLP GEVGKKFNSD GTQDEDEEAE EDEEATGSDE
RLRKHADATK STGEVVMRPK SVTVALTPNG RADAVTRVTY ATAAVPAEDV AGVYAGNEAR
KQAVLLPLLT HAADKDEGDA VRREKIFMYA AELRVTLSQL YGLLQRSPTC PLPHPINVDM
RTYADKHHTP VIAYAQLQNN CLNTEYAHLR VDLCPNVELF GCRVFSKEAV EAANVWFGIP
ASVSSMHQDW VENLYSVVRG VKEFVLIPPW EGPFVPKPEI PAAMFAIDKE ASLMDHEDDR
AESWSLQFKQ YPVKDGTVVP WMDFDLAGAD VEVDAEGAAR AELEDRLLEK RRVSALSSSS
LLTNTGAKQV SNKEDVEAAR EEASRKPLHP LVTYVYPGET LYLPAMWLHR VAQHADSIDL
HARAQHCGAA NAVVSTTPPP LPLTAAVNYW YDMSFSNPAV VLLREFGLLL
//
