ID A4HHK9_LEIBR Unreviewed; 1552 AA.
AC A4HHK9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=CCHC-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_29_2070 {ECO:0000313|EMBL:CAM40063.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40063.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40063.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40063.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40063.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40063.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799004; CAM40063.2; -; Genomic_DNA.
DR RefSeq; XP_001566550.2; XM_001566500.2.
DR STRING; 5660.A4HHK9; -.
DR GeneID; 5417439; -.
DR KEGG; lbz:LBRM_29_2070; -.
DR VEuPathDB; TriTrypDB:LbrM.29.2070; -.
DR VEuPathDB; TriTrypDB:LBRM2903_290027200; -.
DR InParanoid; A4HHK9; -.
DR Proteomes; UP000007258; Chromosome 29.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF341; NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 1188..1263
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1275..1466
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 113..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 172443 MW; A3DCE2682AA8D568 CRC64;
MPLLSEWTEE KNACIDWANP EEVLCNGFTF LQLLAAHPRL RQHYEAVDKQ SERYAVKDIF
LFGSAAEKMT WLTRWHEQSL FYLRLERWCR FCGEKGHTRL RCSQRLCSAS ASASDDPASV
TATNGKDPVA LSAAPSSDVT RPSVLKKHRE HLQRVEQRRI LEEKQKPRTE AGAVRRSGAA
AARASTAVAT TLFTADERRR GVVCRLDEAN NIGFVTVAGM GELKFFVDRV DVGVKTVTVG
DNVTFKLDPS RDYPIAVDVR HERPVITLED VRKFLHRCRA ACHPIKVMAT LLMHAHEWFV
LLRWLHVLRE QDAALYVEAV HTLIELTTFV GNREPIHVPV LSAFLVLLCT TPPSMPRAAA
ATAPGGSTTT FPLATSTAAT ATAAVPPLQL PPFYPDMVRD ALELHTATQK PSAPAAAAAT
AEVRLAEDRW VEVAEFVILV RYYSPLSGAG STAQNGTNET SAMGLEASVD REAVVVRQLQ
AFFAERLTRA SGAALRRLQL AQMRLAQEVR SPAASGTREI TTGAAVFGSA LPGVALIPTA
EEFSVPPPSP ASIFAPANLP VNGATTYTDT HAFIHDQCKL LRADTFEYVS RVLPAVCYSL
PSYTPTQETM SDVQHARVYS RVRCLGKVMT SDHDYSHPES YLLEVHPHSP RANLRAQLHE
GTTLCISTAL DATAMDNKEL FWGVVSSCDA VFMGVGVIAV SPCEASPSFE LMRAALDRNA
ALGRLDRSFL LETPIFMAGY ESIMRALEAF CGPLAMPLPM VRQLVGPQAA ASGDDGHQLV
EYIPPHCAVT FQELTDEIRS QFVLDEGQKA VMRQLPVSKM ILVQGPPGTG KSFIGCRVVE
AYVRYKQLVA SGDILQKVSI DMLRSTRLED LLPQVGPMVV ITYKNHALDE FLLDLLDCGL
WEMNRPRVGQ QLATRMSTAA AGLSPSSSAS AFPGGKRLVR IGGRSREARL DGYNLGALLH
SSMDRAAINS LKDRLFVLNQ RLERLTKEIH YLESGRVPRV YFERWLTAEQ RRHITFDDRE
SWLAGEKYIG ALDEAEDMVS PTHYQSLLQT RMAELLGAQR SQGSSLQANS TAKASPPTGA
TVAERGEEEE EEDVSLSVFQ EMRREEERRE LNNQLHQAYL SAESLLLASQ PPSRPVGVPE
ELLSLWSLTP RLRHEYFAYL IASCIAVKAR DCLTIMETMK SVIRVRRHAM DELKLSLLQG
ADVVGLTTTG CAMNQNLLRS LRPSVLVVEE AAEVLESQML ACMTDSLKQI ILIGDHYQLQ
PKVDTFQYEK TNRLNLSLFE RLAQKTQPIR LTEQRRMHPE ISRLIRPFYS PQPLVDHASV
LTRPFPSASG VAAVDRVPGL AMRVFFWRHC HPEEEAPGSR SKVNTREIRM VQQVVTHLVS
QGVLQKSITV VTPYLGQRRM LRGVLRLRSL ADVQVSTVDL YQGDENDIII LSLVRTEKLT
DFIRTRNRLI VSCSRARFAM VMIGNDELLR QCRHWERVLG QLESEQRIGE SLPITYRDRP
SQVEHMTVVE SVSAAALEAE LTAQQQQRRK TDQRCQPAAV GSAAPESGEG DD
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