ID A4HHS0_LEIBR Unreviewed; 776 AA.
AC A4HHS0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN ORFNames=LBRM_29_2690 {ECO:0000313|EMBL:CAM40125.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40125.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40125.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40125.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40125.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40125.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR799004; CAM40125.2; -; Genomic_DNA.
DR RefSeq; XP_001566611.2; XM_001566561.2.
DR AlphaFoldDB; A4HHS0; -.
DR GeneID; 5417501; -.
DR KEGG; lbz:LBRM_29_2690; -.
DR VEuPathDB; TriTrypDB:LbrM.29.2690; -.
DR VEuPathDB; TriTrypDB:LBRM2903_130007100; -.
DR InParanoid; A4HHS0; -.
DR Proteomes; UP000007258; Chromosome 29.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00065; FYVE_like_SF; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002921; Fungal_lipase-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR PANTHER; PTHR47413; LIPASE-LIKE PAD4; 1.
DR PANTHER; PTHR47413:SF2; LIPASE-LIKE PAD4; 1.
DR Pfam; PF01764; Lipase_3; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 104..157
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 84085 MW; 8C0F4830EE1CC0AC CRC64;
MKKLFGSRSS ANTSSPTPRT TAAPVDPGKR DELYEAAMGD GKGGMVNKDG DVLGSTMTDA
ASIYTGGRQG PDPAKRHGSC YIGGTNGRCG TCGLSKIACN CQTCHCCGRF LMSPSSRHHC
RQCWRATCAD CSTSVRTNDF MGGRVTLTCN FCAVPKALCF VTQMRYSSYD MVGVVDLTMG
NGAGRNYDVS AKPPQPNMRA AMEPCAFRWG VYALGCAVES PRRCINPSCP APLSYAEVCV
KCKTPTVVMT FHEQRHIVMQ NTSMEGKRPE ASDSSVRMVE AVEDAVRSAY DNMATSRTPE
EEEEIFASAL PSGMETQLFS SALSGPAVRK LLLSLVACYI AGESSGTPCV SLALTDLPLY
GRLLRPTNIT ELFTVFDGPG RTRFIAFSSG TTRRSALHQV LGTRMVPREL WSNATMKKEL
VVGKVVGGKE AARKGGLNTN VATWAMRSGL LAYMAEDNIM DRVQSLVLRI VKSSSEVVIC
GHGVGGAAAT WLTTCLLLEN TPETRDRLMC VTFGAPLIAN QSLSEVLIKN DLAKNFHHCV
YGSDMVPRLC YVDSLLLSGN TAGCTFSVGL EEEATSGRRV QECTAAWVAL HEEPHNPADV
AQAMAEIGDD NLSLTNFSSS AQQAPIEGGI DAAPPDKKES SKQPAQPADT AARTAATAMG
DLFLQSREPF GNTSVRTVHK GDDDAKGAVV AGQFNVRDAD FKCFSSPQHR DRQVMDPFGF
YHFFWHPRRK YMCTDDPKVV IAMLSDRTEL RVQLRDHLLS SYNKGMLEYI YSACPE
//
