ID   A4HIJ1_LEIBR            Unreviewed;       622 AA.
AC   A4HIJ1;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=formate--tetrahydrofolate ligase {ECO:0000256|ARBA:ARBA00012295};
DE            EC=6.3.4.3 {ECO:0000256|ARBA:ARBA00012295};
GN   Name=FTHS {ECO:0000313|EMBL:CAM40404.1};
GN   ORFNames=LBRM_30_2550 {ECO:0000313|EMBL:CAM40404.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40404.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM40404.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40404.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM40404.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40404.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
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DR   EMBL; FR799005; CAM40404.1; -; Genomic_DNA.
DR   RefSeq; XP_001566881.1; XM_001566831.1.
DR   AlphaFoldDB; A4HIJ1; -.
DR   STRING; 5660.A4HIJ1; -.
DR   GeneID; 5417780; -.
DR   KEGG; lbz:LBRM_30_2550; -.
DR   VEuPathDB; TriTrypDB:LbrM.30.2550; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_300032000; -.
DR   InParanoid; A4HIJ1; -.
DR   OMA; KFWNLKC; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000007258; Chromosome 30.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 1.10.8.770; -; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:CAM40404.1};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
SQ   SEQUENCE   622 AA;  66734 MW;  9A9EC3655F44CCF1 CRC64;
     MATRKLDCLW PVPADIDIAQ SVDAQPITRI AESASILLSE LNPYGSTRAK VKLSVLRRLE
     SSPNGKYVVV AGMNPTPLGE GKSTTTIGLA QALGAHLHRP CFACIRQPSQ GPTFGIKGGA
     AGGGYSQVIP MEDFNLHGTG DIHAITAANN LLAAALDTRI FHERTQDDAA LYRRLTAELN
     EFTPIMQKRL HKLGIHKTDP KALTQEERVS FARLDVNPDT ISWRRVTDVN DRFLREIEIG
     LGKAEKSITR RTGFDISVAS EVMAILALAD DLADMRQRLG AIQVAKSKAG APVTAEDVGC
     AGAMAVLMKD AIEPTLMQTL EGTPVLVHAG PFGNIAHGNS SVVADRIALK LAGVNGFVLT
     EAGFGADMGC EKFFNIKCRT SGLKPDAAVL VATVRALKFH GGVDPKNAAQ ENAEALRTGM
     SNLLRHIQNI RKFGVPVVVA LNQFSTDTAA ELELVKELAM QEGGAAAVVV TNHWCKGGAG
     AVELAQALIH VTETTPSNFQ LLYPNSASLK EKIETVCREI YGAAGVEYLN NTEEKLADFE
     RMGYGDFPVC MAKTQYSFSH NPELRGAPTG FTVPIRDVCV NCGARFVFPL LGDISTMPGL
     PTRPAYYNID IDCETGKIVG LS
//