ID A4HJK3_LEIBR Unreviewed; 343 AA.
AC A4HJK3;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Putative 3,2-trans-enoyl-CoA isomerase,mitochondrial {ECO:0000313|EMBL:CAM42667.2};
DE EC=5.3.3.8 {ECO:0000313|EMBL:CAM42667.2};
GN ORFNames=LBRM_31_2470 {ECO:0000313|EMBL:CAM42667.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM42667.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM42667.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42667.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM42667.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM42667.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
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DR EMBL; FR799006; CAM42667.2; -; Genomic_DNA.
DR RefSeq; XP_001567240.2; XM_001567190.2.
DR AlphaFoldDB; A4HJK3; -.
DR STRING; 5660.A4HJK3; -.
DR GeneID; 5418153; -.
DR KEGG; lbz:LBRM_31_2470; -.
DR VEuPathDB; TriTrypDB:LbrM.31.2470; -.
DR VEuPathDB; TriTrypDB:LBRM2903_310035500; -.
DR InParanoid; A4HJK3; -.
DR Proteomes; UP000007258; Chromosome 31.
DR GO; GO:0004165; F:delta(3)-delta(2)-enoyl-CoA isomerase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 6.10.250.170; -; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR PANTHER; PTHR11941:SF156; ISOMERASE, MITOCHONDRIAL, PUTATIVE-RELATED; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:CAM42667.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT REGION 31..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 38449 MW; CE2B46831A35EED8 CRC64;
MRRAISSSLT RCAGAAGVTS ALLQLPQHRL QSQAPPGGLQ QGCQQAPKAA HAGHEHSHHP
EPEVEPPRKP TEVPKFVRID TSDKGITNVQ LARPPVNPLS LEFFQELNQW MLWLGSNEET
KAVVISSAIP TVYSAGLDLA EVHNPNPERM SGFWQSFQEM WLIFNSFPKP IIAAITGNAP
AAGCIIAMGC DYRVMARGPK DTTKINRLYR IGLNETKLGL VAPPWTVPAY CHLLGSRQAE
RMLQLGETPL ADDAHKLGLI DEVAPDEEQT IEVAYKQAER FLSVPQKPRL MSRELVRREY
LQMLASDKDR KRDTDAFMKM VLNPEVQHNL ERYLQRLKSR SRK
//